Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy8tm1Ljm mutation
(0 available);
any
Adcy8 mutation
(80 available)
|
|
|
behavior/neurological
|
|
• phase 2 responses to formalin injection are decreased in mutants
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy8tm1Ljm mutation
(0 available);
any
Adcy8 mutation
(80 available)
|
|
|
nervous system
|
|
• following transfection with dominant negative or constitutively active CREB, locus coeruleus neurons fail to exhibit alterations in firing unlike similarly treated wild-type or Adcy1tm1Drs neurons
• following chronic morphine treatment and withdrawal, locus coeruleus neurons fail to exhibit an increase in firing wild-type or Adcy1tm1Drs neurons
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy8tm1Ljm mutation
(0 available);
any
Adcy8 mutation
(80 available)
|
|
|
behavior/neurological
|
|
• mutants take less time to leave a perimeter outlined on a large table top over two test sessions
• on an elevated plus-maze, mutants spend more time in open arms and travel a greater distance than controls, indicating reduced anxiety
• mutants exhibit fewer closed arm SAPs and head dips, take less time to leave the center area to first enter an arm, and exhibit more head dips over the side of the open arms, all indicating reduced anxiety
|
growth/size/body
|
|
• females gain weight until 30 days of age, at which point they remain 10-15% smaller
• males gain weight similarly to wild type up until age 45, at which point they grow more slowly between 45 and 92 days of age, after which weight differences are not significant
• however, food intake is normal
|
nervous system
|
|
• no measurable LTD after low frequency stimulation in hippocampal slices derived from homozygous mice
|
homeostasis/metabolism
taste/olfaction
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1Drs mutation
(0 available);
any
Adcy1 mutation
(70 available)
Adcy8tm1Ljm mutation
(0 available);
any
Adcy8 mutation
(80 available)
|
|
|
behavior/neurological
|
|
• at 1 and 3 days after injection of complete Freunds' adjuvant into the hindpaw, wild-type mice withdraw their hindpaw in response to stimulation of the ipsilateral or contralateral hind paw, but in double knockouts this allodynia is completely abolished
• after nerve injury, reduction in mechanical sensitivity in double knockouts was reduced of abolished compared with wild-type
|
|
|
• phase 2 responses to formalin injection (10-55 minutes after injection) are decreased in mutants, to a greater extent than in Adcy8 knockouts
• phase 3 responses to formalin injection (55-120 minutes following) are decreased in mutants relative to wild-type
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1Drs mutation
(0 available);
any
Adcy1 mutation
(70 available)
Adcy8tm1Ljm mutation
(0 available);
any
Adcy8 mutation
(80 available)
|
|
|
behavior/neurological
|
|
• double knockout animals exhibit passive avoidance learning but display a memory deficit as early as 30 minutes after training; lower latencies are also apparent 24 hours and 8 days after training compared with single knockouts or wild-type; latencies are comparable to controls after forskolin treatment of CA1 of the hippocampus15 minutes before training
|
|
|
• double knockouts exhibit a decrease in freezing behavior compared to wild-type after 8 days in a contextual learning paradigm
|
nervous system
|
|
• sustained L-LTP could not be generated in hippocampal slices from double knockout mice; the fEPSP slope exhibited a significant decrement at all times after tetanus; LTP dropped off after 80 minutes compared to 3 hours in each of the single knockouts
|
Analysis Tools
