Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk10tm1Flv mutation
(2 available);
any
Mapk10 mutation
(37 available)
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behavior/neurological
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• improved performance over controls after treatment with MPTP in a rotorod test but only at low speeds
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nervous system
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• increased resistance to MPTP induced Parkinson's disease
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• 3 fold improvement in neuron survival in the facial motor nucleus after axotomy (37% survive)
• improved neuron survival in dorsal root ganglia as well
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homeostasis/metabolism
cellular
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• increased resistance to MPTP induced Parkinson's disease
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk10tm1Flv mutation
(2 available);
any
Mapk10 mutation
(37 available)
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behavior/neurological
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• resistant to seizures induced by low doses (30mg/kg) of kainic acid
• remain sensitive to pentetrazole induced seizures
• higher doses of kainic acid (45mg/kg)induced seizures similar to those seen in controls but survival was much better, 60% of controls killed by this dose
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nervous system
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• resistant to seizures induced by low doses (30mg/kg) of kainic acid
• remain sensitive to pentetrazole induced seizures
• higher doses of kainic acid (45mg/kg)induced seizures similar to those seen in controls but survival was much better, 60% of controls killed by this dose
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• lower levels of apoptosis (35%) are induced in primary cortical neuron cultures than in wild-type neurons (55%) after 24 hours of treatment with 25 um Abeta25-35 peptide
• similar results are obtained for treated cultured hippocampal neurons or cortical neurons treated with Abeta 1-40
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• resistant to damage seen in pyramidal neurons of CA1 of controls when treated with kainic acid
• resistant to hippocampal cell damage which is evident at 30mg/kg kainic acid dose in control mice; limited damage seen at a 45mg/kg dos
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cardiovascular system
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N |
• exhibit no difference in response to pressure overload compared to wild-type
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cellular
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• in mutants, corticospinal neurons are resistant to lesion-induced cell death whereas ~40% of wild-type CSN die after CSN deafferentation at 4 months of age
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• lower levels of apoptosis (35%) are induced in primary cortical neuron cultures than in wild-type neurons (55%) after 24 hours of treatment with 25 um Abeta25-35 peptide
• similar results are obtained for treated cultured hippocampal neurons or cortical neurons treated with Abeta 1-40
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• resistant to damage seen in pyramidal neurons of CA1 of controls when treated with kainic acid
• resistant to hippocampal cell damage which is evident at 30mg/kg kainic acid dose in control mice; limited damage seen at a 45mg/kg dos
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homeostasis/metabolism
nervous system
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• resistance to MPTP-induced Parkinson's disease
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• much improved neuron survival in the facial motor nucleus after axotomy (52% survive)
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behavior/neurological
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N |
• MPTP treatment had no effect on rotarod performance at any speed
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homeostasis/metabolism
cellular
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• resistance to MPTP-induced Parkinson's disease
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nervous system
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N |
• appear healthy and do not exhibit exencephaly or abnormal apoptosis during brain development
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nervous system
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N |
• do not exhibit exencephaly or show abnormal apoptosis during brain development
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Analysis Tools