Phenotypes associated with this allele

• Allele Symbol: Hoxb8^tm1Mrc
• Allele Name: targeted mutation 1, Mario R Capecchi
• Allele ID: MGI:2159734
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb8^tm1Mrc/Hoxb8^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:2673420

Genotype
MGI:2673420

hm1

• Allelic Composition: Hoxb8^tm1Mrc/Hoxb8^tm1Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal rib development ( J:73745 )

• 74% exhibit defects in the formation of the first rib, with 75% of these showing a bilateral defect

• rib defects include fusion of the first and second ribs near their attachment point at the sternum and complete absence of a rib adjacent to the first thoracic vertebra

behavior/neurological

increased grooming behavior ( J:73745 )

integument

abnormal coat appearance ( J:73745 )

• varied hair loss due to excessive grooming resluting in bald patches

abnormal skin condition ( J:73745 )

• self-inflicted lesions due to excessive grooming