Phenotypes associated with this allele

• Allele Symbol: Mcl1^tm1Sjk
• Allele Name: targeted mutation 1, Stanley J Korsmeyer
• Allele ID: MGI:2159362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcl1^tm1Sjk/Mcl1^tm1Sjk	involves: 129X1/SvJ * C57BL/6	MGI:2177806

Genotype
MGI:2177806

hm1

• Allelic Composition: Mcl1^tm1Sjk/Mcl1^tm1Sjk
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:59429 )

N • null embryos do not exhibit an increase in apoptotic cells

failure of blastocyst to hatch from the zona pellucida ( J:59429 )

• null blastocyts fail to hatch from the zona pellucida

embryonic growth arrest ( J:59429 )

• homozygous embryos arrest by the blastomere stage

mortality/aging

embryonic lethality at implantation, complete penetrance ( J:59429 )

• no homozygous embryos are found at implantation or beyond

embryonic lethality before implantation, incomplete penetrance ( J:59429 )

• 16% of blastocyts and morulae at preimplantation stages are homozygous, less than expected

reproductive system

abnormal embryo attachment ( J:59429 )

• null blastocyts fail to attach to substrate in vitro