Phenotypes associated with this allele

• Allele Symbol: Wasl^tm1.1Cgn
• Allele Name: targeted mutation 1.1, University of Cologne
• Allele ID: MGI:2159338
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wasl^tm1.1Cgn/Wasl^tm1.1Cgn	C57BL/6-Wasl^tm1.1Cgn	MGI:3665164

Genotype
MGI:3665164

hm1

• Allelic Composition: Wasl^tm1.1Cgn/Wasl^tm1.1Cgn
• Genetic Background: C57BL/6-Wasl^tm1.1Cgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:73609 )

• no homozygotes are born; time of lethality not specified

embryo

abnormal gastrulation ( J:73609 )

• gastrulation has not not started at E8.5

failure of initiation of embryo turning ( J:73609 )

• fail to undergo turning

abnormal mesoderm development ( J:73609 )

• show abnormalities of intra-embryonal mesoderm differentiation

decreased embryo size ( J:73609 )

abnormal allantois morphology ( J:73609 )

• the allantois shows widening of the intercellular spaces distally and does not contribute to the placenta

abnormal ectoplacental cavity morphology ( J:73609 )

• at E8.5, although the epithelia of parietal and visceral yolk sac are formed, the ectoplacental cavity is sill round as normally seen at E7

abnormal extraembryonic mesoderm development ( J:73609 )

• show abnormalities of extra-embryonal mesoderm differentiation

growth/size/body

decreased embryo size ( J:73609 )