Phenotypes associated with this allele

• Allele Symbol: Drd1^tm1Stl
• Allele Name: targeted mutation 1, Susumu Tonegawa
• Allele ID: MGI:2159306
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Drd1^tm1Stl/Drd1^tm1Stl	involves: 129P2/OlaHsd	MGI:3806625
hm2	Drd1^tm1Stl/Drd1^tm1Stl	involves: 129P2/OlaHsd * C57BL/6	MGI:3806618
hm3	Drd1^tm1Stl/Drd1^tm1Stl	involves: 129P2/OlaHsd * C57BL/6J	MGI:3806626

Genotype
MGI:3806625

hm1

• Allelic Composition: Drd1^tm1Stl/Drd1^tm1Stl
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:112986 )

• the electrophysiological effects of dopamine, SKF38393 and quinpirole on neuron firing are reduced

• however, serotonin induced inhibition of glutamate-induced firing is normal

decreased physiological sensitivity to xenobiotic ( J:112986 )

• nucleus accumbens neurons are less sensitive to cocaine than in wild-type mice

behavior/neurological

impaired behavioral response to cocaine ( J:112986 )

• mice fail to exhibit an increase in activity following administration of cocaine

increased exploration in new environment ( J:112986 )

• mice are hyperactive in a novel environment

hyperactivity ( J:112986 )

• mice are hyperactive in a novel environment

Genotype
MGI:3806618

hm2

• Allelic Composition: Drd1^tm1Stl/Drd1^tm1Stl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:21603 )

• fewer than expected mice are present at weaning

nervous system

decreased brain size ( J:21603 )

decreased striatum size ( J:21603 )

• smaller than in wild-type mice

behavior/neurological

impaired behavioral response to xenobiotic ( J:21603 )

• unlike wild-type mice, treatment with SKF81297, a Drd1a agonist, does not result in increased locomotion during the light phase

• unlike in wild-type mice, treatment with SCH23390,a Drd1a antagonist, does not result in decreased locomotion during the dark phase nor do mice exhibit a catalepsy response in a dose-dependent manner

hyperactivity ( J:21603 )

• mice are more active than wild-type mice during light and dark phases

growth/size/body

decreased body size ( J:21603 )

decreased body weight ( J:21603 )

• less than 30%

Genotype
MGI:3806626

hm3

• Allelic Composition: Drd1^tm1Stl/Drd1^tm1Stl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

behavior/neurological

impaired behavioral response to xenobiotic ( J:127798 )

• mice fail to exhibit self-administration behavior for cocaine, SKF82958 or quineorane observed in wild-type mice even with food reinforcement

• however, self-administration behavior for remifentanil is normal

impaired behavioral response to cocaine ( J:127798 )

• mice fail to exhibit self-administration behavior for cocaine observed in wild-type mice even with food reinforcement