Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1Gan mutation
(0 available);
any
Atoh7 mutation
(9 available)
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vision/eye
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• at E16.5, there is a 65% increase in the number of apoptotic cells compared to controls
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• a thin optic nerve is observed
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• higher number of retinal cells are actively proliferating at E16.5
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• Muller cells are mislocalized to the ganglion cell layer and the outer nuclear layer
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• projections of ganglions are often disorganized though a few do project into the optic disc
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• retinal ganglion cells are decreased by about 95%
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• the amplitudes of b waves for both scotopic and phototopic ERG are significantly reduced
• there is also a loss of positive scotopic threshold response
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nervous system
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• Muller cells are mislocalized to the ganglion cell layer and the outer nuclear layer
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• projections of ganglions are often disorganized though a few do project into the optic disc
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• retinal ganglion cells are decreased by about 95%
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• a thin optic nerve is observed
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cellular
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• at E16.5, there is a 65% increase in the number of apoptotic cells compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1Gan mutation
(0 available);
any
Atoh7 mutation
(9 available)
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reproductive system
vision/eye
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• 7.5-fold increase in the number of ON-starburst (ChAT+) cells most of which are displaced to the ganglion cell layer
• however, bipolar cells are normal in number
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nervous system
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• 7.5-fold increase in the number of ON-starburst (ChAT+) cells most of which are displaced to the ganglion cell layer
• however, bipolar cells are normal in number
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1Gan mutation
(0 available);
any
Atoh7 mutation
(9 available)
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vision/eye
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• the number of Bhlhb5+ displaced amacrine cells in increased 7-fold at P21
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• the number of cone bipolar cells is reduced
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nervous system
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• the number of Bhlhb5+ displaced amacrine cells in increased 7-fold at P21
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• the number of cone bipolar cells is reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1Gan mutation
(0 available);
any
Atoh7 mutation
(9 available)
Atoh7tm1(Neurod1)Whk mutation
(0 available);
any
Atoh7 mutation
(9 available)
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vision/eye
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• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice
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• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 40% of wild-type but increases by E14.5 likely due to delayed RGC differentiation
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• at P30 to P40, two-thirds of retinas exhibit greater numbers and higher density of retinal ganglion cell axon bundles compared to in Atoh7tm1Gan homozygotes with the majority correctly orientated towards the optic disk
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• mice exhibit severe optic nerve hypoplasia
• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves
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nervous system
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• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 40% of wild-type but increases by E14.5 likely due to delayed RGC differentiation
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• at P30 to P40, two-thirds of retinas exhibit greater numbers and higher density of retinal ganglion cell axon bundles compared to in Atoh7tm1Gan homozygotes with the majority correctly orientated towards the optic disk
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• mice exhibit severe optic nerve hypoplasia
• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves
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cellular
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• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1Gan mutation
(0 available);
any
Atoh7 mutation
(9 available)
Atoh7tm2(Neurod4)Whk mutation
(0 available);
any
Atoh7 mutation
(9 available)
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vision/eye
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• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 10% of wild-type but increases by E14.5 likely due to delayed RGC differentiation
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nervous system
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• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 10% of wild-type but increases by E14.5 likely due to delayed RGC differentiation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1Gan mutation
(0 available);
any
Atoh7 mutation
(9 available)
Atoh7tm2Gan mutation
(0 available);
any
Atoh7 mutation
(9 available)
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vision/eye
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• at E15.5, the ganglion cell layer contains very few differentiated ganglion cells
• however, at E11 and E15.5 the number of progenitor retinal ganglion cells are similar to that in heterozygotes and there is no evidence of increased apoptosis at E12.5 to E19
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• absence of nerve fiber layer
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nervous system
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• at E15.5, the ganglion cell layer contains very few differentiated ganglion cells
• however, at E11 and E15.5 the number of progenitor retinal ganglion cells are similar to that in heterozygotes and there is no evidence of increased apoptosis at E12.5 to E19
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1Gan mutation
(0 available);
any
Atoh7 mutation
(9 available)
Pou4f2tm1Nat mutation
(0 available);
any
Pou4f2 mutation
(7 available)
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vision/eye
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• at E16.5, there is a 65% increase in the number of apoptotic cells compared to controls
• at day of birth, apoptotic numbers are 500% greater than in controls
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• a higher number of retinal cells are actively proliferating at E16.5
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• Muller cells are reduced by about 30%
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• there is a 70% reduction of amacrine cells
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• rod bipolar cells are reduced by 45% and are found in patches instead of being evenly distributed
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• the small number of retinal ganglion cells have small and underdeveloped axons
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• retinal ganglion cells are virtually absent with less than 1% of the normal number present
• cells are absent at birth suggesting an early developmental defect
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• the virtual absent of retinal ganglion cells leads to a decrease in layer thickness
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• there is a 65% reduction in the number of cells found in the inner nuclear layer including a 70% reduction of amacrine cells
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• there is a 50% reduction in the number of cells found in the outer nuclear layer
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• retinal thickness at the day of birth is reduced by about 50% compared to controls
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• b waves are significantly reduced under scotopic conditions and are absent under photopic conditions
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nervous system
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• Muller cells are reduced by about 30%
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• there is a 70% reduction of amacrine cells
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• rod bipolar cells are reduced by 45% and are found in patches instead of being evenly distributed
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• the small number of retinal ganglion cells have small and underdeveloped axons
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• retinal ganglion cells are virtually absent with less than 1% of the normal number present
• cells are absent at birth suggesting an early developmental defect
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cellular
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• at E16.5, there is a 65% increase in the number of apoptotic cells compared to controls
• at day of birth, apoptotic numbers are 500% greater than in controls
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Analysis Tools