Phenotypes associated with this allele

• Allele Symbol: Calb2^tm1Map
• Allele Name: targeted mutation 1, Marc Parmentier
• Allele ID: MGI:2158756
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Calb2^tm1Map/Calb2^tm1Map	involves: 129P2/OlaHsd * C57BL/6JIco	MGI:2659018

Genotype
MGI:2659018

hm1

• Allelic Composition: Calb2^tm1Map/Calb2^tm1Map
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6JIco

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:42924 )

N • mutants exhibit normal exploratory activity, pain sensitivity, motor coordination on a rotarod, and spatial memory despite impaired LTP

impaired coordination ( J:54517 )

• in a wheel running test, 4-6 week old mutants show fewer number of steps per minute and reduced total horizontal displacement of the hindlimb foot

• in the presence of a sensory perturbation, locomotion remains poor and elevations of the hindfoot are induced

• the feet of aged (18-24 months) mutants slip more often that those of wild-type in the runway test

• aged mutants spend less time on a rotarod than wild-type

• in a wheel running test, aged mutants frequently fall after hindfoot elevations in the presence of a sensory perturbation

nervous system

abnormal nervous system electrophysiology ( J:54517 )

• severe impairment of Purkinje cell firing properties, with a doubling of the spontaneous simple spike firing rate, a halving of the duration of complex spike, and a 70-80% reduction in the duration of the simple spike pause after the complex spike

• however, excitatory and synaptic transmission and short-term plasticity are normal in cerebellar slices

abnormal long-term potentiation ( J:42924 )

• induction of long-term potentiation (LTP) is impaired in the dentate gyrus; mutants show a reduced posttetanic potentiation that decays progressively over time

• however, LTP is induced normally in CA1 region