About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Casp1tm1Flv
targeted mutation 1, Richard Flavell
MGI:2158744
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Casp1tm1Flv/Casp1tm1Flv involves: 129S2/SvPas * C57BL/6N MGI:6452824
ht2
Casp1tm1Flv/Casp1+ involves: 129S2/SvPas * C57BL/6N MGI:6452825
cx3
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
B6.129S2-Casp1tm1Flv MGI:3711186
cx4
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Slc11a1s/Slc11a1s
B6.129S2-Casp1tm1Flv MGI:3722759
cx5
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Slc11a1r/Slc11a1r
involves: 129S2/SvPas MGI:3722760
cx6
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
involves: 129S2/SvPas MGI:4839914
cx7
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Il1r1tm1Imx/Il1r1tm1Imx
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:2179470
cx8
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
involves: 129S2/SvPas * C57BL/6 MGI:2179469
cx9
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
involves: 129S2/SvPas * C57BL/6J MGI:5467384
cx10
Casp1tm1Flv/Casp1tm1Flv
St18tm1c(KOMP)Wtsi/St18tm1c(KOMP)Wtsi
involves: C57BL/6 * C57BL/6N * DBA/2 MGI:6489911


Genotype
MGI:6452824
hm1
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Genetic
Background
involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• normal body weight after inducing persistent hyperglycemia in uninephrectomized mice

homeostasis/metabolism
• no albuminuria after inducing persistent hyperglycemia in uninephrectomized mice
• normal blood glucose level after inducing persistent hyperglycemia in uninephrectomized mice

renal/urinary system
N
• normal mesangial matrix after inducing persistent hyperglycemia in uninephrectomized mice




Genotype
MGI:6452825
ht2
Allelic
Composition
Casp1tm1Flv/Casp1+
Genetic
Background
involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• normal body weight after inducing persistent hyperglycemia in uninephrectomized mice

homeostasis/metabolism
N
• normal blood glucose level after inducing persistent hyperglycemia in uninephrectomized mice
• no albuminuria after inducing persistent hyperglycemia in uninephrectomized mice

renal/urinary system
N
• normal mesangial matrix after inducing persistent hyperglycemia in uninephrectomized mice




Genotype
MGI:3711186
cx3
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Genetic
Background
B6.129S2-Casp1tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (30 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• reduced compared to controls after LPS induced acute kidney failure but not significantly

renal/urinary system
• reduced compared to controls after LPS induced acute kidney failure but not significantly
• reduced after LPS induced acute kidney failure but less than in controls
• LPS induced acute kidney failure is also less severe

digestive/alimentary system
• mice and co-housed wild-type mice exhibit expanded bacterial phylotypes compared with wild-type mice
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice

immune system
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice
• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium




Genotype
MGI:3722759
cx4
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Slc11a1s/Slc11a1s
Genetic
Background
B6.129S2-Casp1tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (30 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when infected with 105 Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice

immune system
• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption
• when infected with 105 Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice
• when infected with 106 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased to a greater extent than in either single allele homozygote
• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1s homozygotes

digestive/alimentary system
• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption




Genotype
MGI:3722760
cx5
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Slc11a1r/Slc11a1r
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (30 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when infected with 106 Salmonella typhimurium, mice have a shorter time to death than Slc11a1r homozygotes

immune system
• when infected with 106 Salmonella typhimurium, mice have a shorter time to death than Slc11a1 homozygotes
• when infected with 106 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased relative to in Slc11a1 homozygotes
• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1r homozygotes




Genotype
MGI:4839914
cx6
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (30 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 3 of 16 mice injected with B16M cells die after 12 days compared to all similarly treated wild-type mice

neoplasm
• mice injected with B16 cells exhibit reduced metastasis (by volume and density) in the liver compared with similarly treated wild-type mice
• mice injected with B16 cells exhibit decreased metastasis volume, an indicator of metastatic growth, compared with similarly treated wild-type mice
• mice injected with B16 cells exhibit decreased metastasis volume, an indicator of metastatic growth, compared with similarly treated wild-type mice




Genotype
MGI:2179470
cx7
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Il1r1tm1Imx/Il1r1tm1Imx
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (30 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
Il1r1tm1Imx mutation (4 available); any Il1r1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• resistance to endotoxin shock induced by high dose lipopolysaccharide (LPS)




Genotype
MGI:2179469
cx8
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (30 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Fas mediated apoptosis in thymocytes is suppressed
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired
• serum levels are reduced in mice given Il12 daily
• significantly reduced levels of Ifn gamma are induced by Il12 in splenocytes
• no Il1 alpha is released by monocytes in response to LPS
• no Il1 beta is released by monocytes in response to LPS
• significantly lower levels of Il18 are released by cultured splenocytes
• Il12 treatment fails to cause increased Il18 release but liver and spleen levels increase comparable to controls
• secretion by monocytes in response to LPS is reduced
• secretion by monocytes in response to LPS is reduced
• 10 fold increase in survival (from 6% in wild-type to 60%) of mice challenged with a high dose of LPS
• macrophages infected with Legionella and cultured for 72 hours show a 200-fold increase in bacterial number

renal/urinary system
• reduced after ischemic reperfusion as compared to controls
• ischemic acute renal failure is less severe than in controls

homeostasis/metabolism
• serum levels are reduced in mice given Il12 daily

hematopoietic system
• Fas mediated apoptosis in thymocytes is suppressed
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

cellular
• Fas mediated apoptosis in thymocytes is suppressed
• reduced after ischemic reperfusion as compared to controls
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

endocrine/exocrine glands
• Fas mediated apoptosis in thymocytes is suppressed




Genotype
MGI:5467384
cx9
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (30 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit later onset and a lower incidence of tumors compared with type mice

integument
N
• untreated or TPA, TNF or EGF-treated keratinocytes exhibit normal proliferation

homeostasis/metabolism
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit later onset and a lower incidence of tumors compared with type mice




Genotype
MGI:6489911
cx10
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
St18tm1c(KOMP)Wtsi/St18tm1c(KOMP)Wtsi
Genetic
Background
involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (30 available)
St18tm1c(KOMP)Wtsi mutation (0 available); any St18 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced survival rates after LPS injection





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
01/24/2023
MGI 6.22
The Jackson Laboratory