Phenotypes associated with this allele

• Allele Symbol: Srf^tm1Nor
• Allele Name: targeted mutation 1, Alfred Nordheim
• Allele ID: MGI:2158696
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srf^tm1Nor/Srf^tm1Nor	involves: 129P2/OlaHsd	MGI:3608114

Genotype
MGI:3608114

hm1

• Allelic Composition: Srf^tm1Nor/Srf^tm1Nor
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:50876 )

• no embryos detected after E12.5

embryo

abnormal gastrulation ( J:50876 )

• display aberrant folding of ectoderm and endoderm at E7.5 and E8.5

embryonic growth retardation ( J:50876 )

• at E7.5, exhibit delayed development and display late egg cylinder stage morphology

decreased embryo size ( J:50876 )

• embryos are smaller at E7.5 but appear normal at E6.5

absent mesoderm ( J:50876 )

failure of primitive streak formation ( J:50876 )

growth/size/body

embryonic growth retardation ( J:50876 )

• at E7.5, exhibit delayed development and display late egg cylinder stage morphology

decreased embryo size ( J:50876 )

• embryos are smaller at E7.5 but appear normal at E6.5