All Phenotypes C3ar1<tm1Cge> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C3ar1^tm1Cge/C3ar1^tm1Cge	B6.129S4(C)-C3ar1^tm1Cge	MGI:6382538
hm2	C3ar1^tm1Cge/C3ar1^tm1Cge	involves: 129S4/SvJae * BALB/c	MGI:2449064
hm3	C3ar1^tm1Cge/C3ar1^tm1Cge	involves: 129S4/SvJae * C57BL/6	MGI:5295997
cx4	C3ar1^tm1Cge/C3ar1^tm1Cge C5ar1^tm1Cge/C5ar1^tm1Cge	B6.Cg-C3ar1^tm1Cge C5ar1^tm1Cge	MGI:6382540

Allelic Composition	C3ar1^tm1Cge/C3ar1^tm1Cge
Genetic Background	B6.129S4(C)-C3ar1^tm1Cge

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3ar1^tm1Cge mutation (2 available); any C3ar1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

increased retina apoptosis ( J:214214 )

• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months

abnormal retina rod bipolar cell morphology ( J:214214 )

• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age

abnormal retina horizontal cell morphology ( J:214214 )

• density of horizontal cells is decreased

thin retina inner nuclear layer ( J:214214 )

• the inner nuclear layer is thinner at 3 and 14 months of age

thin retina outer nuclear layer ( J:214214 )

• outer nuclear layer thinning is seen at older ages

disorganized retina outer nuclear layer ( J:214214 )

• the outer nuclear layer is disorganized at 3 months of age

increased susceptibility to age-related retinal degeneration ( J:214214 )

• mice show progressive retinal cell loss

decreased a-wave amplitude ( J:214214 )

• by 14 weeks of age, but not at 6 weeks, ERG a-waves are reduced and the reduction progresses with increasing age

• after an 8-hour light exposure, mice show a greater loss of retinal function than wild-type mice, showing decreased a-wave amplitude

decreased b-wave amplitude ( J:214214 )

• by 14 weeks of age, but not at 6 weeks, ERG b-waves are reduced and the reduction progresses with increasing age

• after an 8-hour light exposure, mice show a greater loss of retinal function than wild-type mice, showing decreased b-wave amplitude

abnormal c-wave shape ( J:214214 )

• the amplitude of the c-wave is reduced at 12 months of age, but not at 8 weeks of age

• however, no other component of the dc-ERG is different

nervous system

abnormal retina rod bipolar cell morphology ( J:214214 )

• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age

abnormal retina horizontal cell morphology ( J:214214 )

• density of horizontal cells is decreased

homeostasis/metabolism

decreased circulating free fatty acids level ( J:214214 )

• plasma free polyunsaturdated fatty acid (linoleic acid and arachidonic acid) levels are decreased at 14 months of age

decreased circulating phospholipid level ( J:214214 )

• plasma lysophosphatidylcholine levels are decreased at 3 and 14 months of age

cellular

increased retina apoptosis ( J:214214 )

• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months

Allelic Composition	C3ar1^tm1Cge/C3ar1^tm1Cge
Genetic Background	involves: 129S4/SvJae * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3ar1^tm1Cge mutation (2 available); any C3ar1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:64378 )

N	• homozygotes are obtained at the expected Mendelian ratios, are fertile and display no gross developmental or morphological defects when raised under SPF conditions

respiratory system

decreased airway responsiveness ( J:64378 )

• in an ovalbumin-induced model of allergic asthma, unrestrained conscious homozygotes fail to exhibit increased airway hyper-responsiveness (AHR) in response to inhaled methacholine

• similar results are obtained using the same protocol with anesthetized, mechanically ventilated homozygotes and measuring AHR in response to intravenous methacholine

• at 6 or 24 hrs after last allergen challenge, homozygotes show no significant differences in eosinophil numbers (in either BAL or lung tissue), IgE levels or BAL fluid levels of interleukin IL-4, IL-5 and IL-13 relative to wild-type mice

Allelic Composition	C3ar1^tm1Cge/C3ar1^tm1Cge
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3ar1^tm1Cge mutation (2 available); any C3ar1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased osteoclast cell number ( J:166640 )

• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls

immune system

decreased osteoclast cell number ( J:166640 )

• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls

decreased circulating interleukin-6 level ( J:166640 )

• Il-6 production after vitamin D3 stimulation is significantly reduced

hematopoietic system

decreased osteoclast cell number ( J:166640 )

• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:166640 )

• Il-6 production after vitamin D3 stimulation is significantly reduced

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

increased retina apoptosis ( J:214214 )

• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months

• mice immunized with 4-HNE-adducted protein (HNE-MSA) show elevated cell apoptosis as indicated by elevated annexin V levels compared to wild-type mice

abnormal retina rod bipolar cell morphology ( J:214214 )

• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age

abnormal retina horizontal cell morphology ( J:214214 )

• density of horizontal cells is decreased

abnormal photoreceptor outer segment disc membrane morphology ( J:214214 )

• the normal structure of the outer segment discs is lost at 6 months of age

abnormal retina pigment epithelium morphology ( J:214214 )

• retinal pigment epithelium (RPE) cell nuclei are shrunken or apoptotic at 6 months

thin retina inner nuclear layer ( J:214214 )

• the inner nuclear layer is thinner at 3 and 14 months of age

thin retina outer nuclear layer ( J:214214 )

• outer nuclear layer thinning is seen at older ages

disorganized retina outer nuclear layer ( J:214214 )

• the outer nuclear layer is disorganized at 3 months of age

increased susceptibility to age-related retinal degeneration ( J:214214 )

• mice show progressive retinal cell loss

abnormal electroretinogram waveform feature ( J:214214 )

• the fast oscillation is reduced at 6 months of age

• mice immunized with 4-HNE-adducted protein (HNE-MSA) show a more severe reduction in ERG amplitude, however this phenotype is not related to immune responses as IL17-producting cells are diminished

decreased a-wave amplitude ( J:214214 )

• by 14 weeks of age, but not at 6 weeks, ERG a-waves are reduced and the reduction progresses with increasing age

decreased b-wave amplitude ( J:214214 )

• by 14 weeks of age, but not at 6 weeks, ERG b-waves are reduced and the reduction progresses with increasing age

abnormal c-wave shape ( J:214214 )

• the amplitude of the c-wave is reduced at 6 months of age

homeostasis/metabolism

decreased circulating free fatty acids level ( J:214214 )

• plasma free polyunsaturdated fatty acid (linoleic acid and arachidonic acid) levels are decreased at 14 months of age

decreased circulating phospholipid level ( J:214214 )

• plasma lysophosphatidylcholine levels are decreased at 3 and 14 months of age

cellular

increased retina apoptosis ( J:214214 )

• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months

• mice immunized with 4-HNE-adducted protein (HNE-MSA) show elevated cell apoptosis as indicated by elevated annexin V levels compared to wild-type mice

nervous system

abnormal retina rod bipolar cell morphology ( J:214214 )

• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age

abnormal retina horizontal cell morphology ( J:214214 )

• density of horizontal cells is decreased

abnormal photoreceptor outer segment disc membrane morphology ( J:214214 )

• the normal structure of the outer segment discs is lost at 6 months of age

pigmentation

abnormal retina pigment epithelium morphology ( J:214214 )

• retinal pigment epithelium (RPE) cell nuclei are shrunken or apoptotic at 6 months

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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