Phenotypes associated with this allele

• Allele Symbol: Prkar1b^tm1Gsm
• Allele Name: targeted mutation 1, G Stanley McKnight
• Allele ID: MGI:2158640
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkar1b^tm1Gsm/Prkar1b^tm1Gsm	involves: 129X1/SvJ * C57BL/6	MGI:3041527
hm2	Prkar1b^tm1Gsm/Prkar1b^tm1Gsm	Not Specified	MGI:3041528

Genotype
MGI:3041527

hm1

• Allelic Composition: Prkar1b^tm1Gsm/Prkar1b^tm1Gsm
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:30405 )

N • normal exploratory behavior in open field test

N • no differences in leaning, defecation, rearing, or grooming

N • normal spatial reference memory in Barnes maze task

N • normal spatial learning in Morris water maze

N • normal context conditioning

N • normal cued conditioning

nervous system

nervous system phenotype ( J:28735 , J:30405 )

N • normal LTP in Schaffer collateral-CA1 synapse (J:28735)

N • gross neural anatomy of hippocampus appeared normal (J:28735)

N • normal LTP in response to forskolin (J:30405)

reduced long-term potentiation ( J:30405 )

• decreased in mossy fiber pathways

reduced long-term depression ( J:28735 )

• with associated inability to maintain stable depotentiation at the Schaffer collateral-CA1 synapse and lateral perforant path-dentate granule cell synapse

Genotype
MGI:3041528

hm2

• Allelic Composition: Prkar1b^tm1Gsm/Prkar1b^tm1Gsm
• Genetic Background: Not Specified

behavior/neurological

behavior/neurological phenotype ( J:43080 )

N • no difference from controls in response to acute thermal and mechanical pain

N • indices of pain produced by nerve injury similar to controls

abnormal nociception after inflammation ( J:43080 )

• reduced pain after intraplanar formalin injection

increased thermal nociceptive threshold ( J:43080 )

• while baseline response to thermal stimulus was similar to controls, mutant mice showed less thermal allodynia after PGE2 injection compared to controls

immune system

decreased inflammatory response ( J:43080 )

• reduced plasma extravasation in response to intradermal capsaicin injection in the paw