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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2a1atm1Sen
targeted mutation 1, Fujiro Sendo
MGI:2158426
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl2a1atm1Sen/Bcl2a1atm1Sen involves: 129P2/OlaHsd * C57BL/6 MGI:2176731


Genotype
MGI:2176731
hm1
Allelic
Composition		 Bcl2a1atm1Sen/Bcl2a1atm1Sen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2a1atm1Sen mutation (0 available); any Bcl2a1a mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil physiology ( J:52127 )
• enhanced spontaneous apoptosis of peripheral blood neutrophils and peritoneal exudate neutrophils grown in vitro
• neutrophil apoptosis inhibition induced by lipopolysaccharide treatment in vitro or transendothelial migration in vivo seen in wild-type mice is abolished in mutants

integument
focal hair loss ( J:52127 )
• hair loss on head and face by 8-12 weeks of age

hematopoietic system
abnormal neutrophil physiology ( J:52127 )
• enhanced spontaneous apoptosis of peripheral blood neutrophils and peritoneal exudate neutrophils grown in vitro
• neutrophil apoptosis inhibition induced by lipopolysaccharide treatment in vitro or transendothelial migration in vivo seen in wild-type mice is abolished in mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory