All Phenotypes Atp2b2<Tmy> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atp2b2^Tmy
tommy
MGI:2158375

Summary

2 genotypes

Allelic Composition	Atp2b2^Tmy/Atp2b2^Tmy
Genetic Background	involves: BALB/c * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2^Tmy mutation (2 available); any Atp2b2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:167344 )

• visibly smaller than litter mates in 22% of homozygotes showing a more severe phenotype

hearing/vestibular/ear

• increased ABR thresholds indicate a profound hearing impairment at 18 days in 22% of homozygotes showing a more severe phenotype

deafness ( J:167344 )

• deaf from birth in 22% of homozygotes showing a more severe phenotype

behavior/neurological

ataxia ( J:167344 )

• severe ataxia in 22% of homozygotes showing a more severe phenotype

abnormal gait ( J:167344 )

• hesitant, wobbly gait in 22% of homozygotes showing a more severe phenotype

• frequent hyperextension of rear limbs in 22% of homozygotes showing a more severe phenotype

Allelic Composition	Atp2b2^Tmy/Atp2b2⁺
Genetic Background	involves: BALB/c * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2^Tmy mutation (2 available); any Atp2b2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:167344 )

N	• middle ear and inner ear gross morphology is normal

• significant difference in response when compared to controls with clicks or at burst frequencies of 14 kHz or higher

deafness ( J:167344 )

• hearing is normal at 4 weeks as determined by flick preyer response to a transient 20kHz pure tone

• profound deafness first observed at around 12 weeks of age and fully penetrant after 30 weeks

syndromic hearing loss ( J:169366 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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