Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1Dlo mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
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nervous system
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• E12 dorsal root ganglia, brainstem and spinal cord have many more TUNEL positive cells than in wildtype mice
• E12 primary telencephalic cultures show increased apoptosis at 48 hours relative to wildtype or heterozyous cultures
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cellular
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• E12 dorsal root ganglia, brainstem and spinal cord have many more TUNEL positive cells than in wildtype mice
• E12 primary telencephalic cultures show increased apoptosis at 48 hours relative to wildtype or heterozyous cultures
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1Dlo mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
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hematopoietic system
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• platelet counts are significantly lower than controls (860x103/microliter vs 1100x103/microliter)
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• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt20 mutation
(1 available);
any
Bcl2l1 mutation
(104 available)
Bcl2l1tm1Dlo mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
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hematopoietic system
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• platelet counts are 25% of normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1.1Mam mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
Bcl2l1tm1Dlo mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
Tg(Aicda-cre)9Mbu mutation
(2 available)
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immune system
N |
• affinity maturation among NP-reactive B cells and germinal cell formation are normal
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• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice
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hematopoietic system
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• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation
(2 available);
any
Bak1 mutation
(23 available)
Bcl2l1tm1Dlo mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
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hematopoietic system
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• platelet cell numbers are about 50% higher than controls
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• platelet half-life is significantly increased by about 50% compared to controls
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation
(2 available);
any
Bak1 mutation
(23 available)
Bcl2l1tm1Dlo mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
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hematopoietic system
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• the low platelet numbers of Bcl2l1tm1Dlo heterozygotes do not occur in these mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm1Dlo mutation
(0 available);
any
Bax mutation
(24 available)
Bcl2l1tm1Dlo mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
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mortality/aging
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• double heterozygous intercrosses yield no double homozygous liveborn
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nervous system
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• E12 brainstem and ventral spinal cord and E12 primary telencephalic cultures have fewer TUNEL positive cells than Bcl2l1tm1Dlo homozygotes with one or two copies of wildtype Bax
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cellular
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• E12 brainstem and ventral spinal cord and E12 primary telencephalic cultures have fewer TUNEL positive cells than Bcl2l1tm1Dlo homozygotes with one or two copies of wildtype Bax
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1Dlo mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
Casp9tm1Flv mutation
(0 available);
any
Casp9 mutation
(20 available)
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nervous system
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• E12.5 brainstem and dorsal root ganglia, show increased numbers of apoptotic cells, and E12.5 primary telencephalic cultures show increased caspase 3 activation and cell death
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cellular
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• E12.5 liver show increased apoptotic cells
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• E12.5 brainstem and dorsal root ganglia, show increased numbers of apoptotic cells, and E12.5 primary telencephalic cultures show increased caspase 3 activation and cell death
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1Dlo mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
Casp9tm1Flv mutation
(0 available);
any
Casp9 mutation
(20 available)
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cellular
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• at E12.5 brainstem and dorsal root ganglia do not have the apoptosis found in Bcl2tm1Dlo homozygotes, and E12.5 primary telencephalic cultures show decreased cell death and no caspase 3 activation relative to those of Bcl2l1tm1Dlo homozygotes
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• E12.5 liver has increased apoptosis similar to that seen in Bcl2l1tm1Dlo homozygotes indicating no requirement for caspase 9 in liver apoptotis
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nervous system
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• E12.5 histology shows thickened telencephalic vesicle, expanded ventricular zones, and cortical dysplasia
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