Analysis Tools|
Allele Symbol Allele Name Allele ID |
En2+ wild type MGI:2158296 |
||||||||||||||||||||||||||||||||||||||||||||
| Summary |
10 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• when given tamoxifen at E10.5, at P21 the anterior region (lobules I-V) is reduced and the central region (lobules VI-VII) is preferentially expanded.
|
|
• when tamoxifen is given at E10.5, at P21 lobule VIII extends more laterally than normal, as do lobules I-V but only on one side
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• when tamoxifen is given at E13.5 or E14.5 in adult preculminate (between I-II and III) as lobules I-III are fused
|
|
• when tamoxifen is given at E10.5, at P14 lobules VI-VII occupied a greater proportion of the vermis than in wild-type
• when tamoxifen is given at E10.5, at P14 lobules VIII-IX occupied a smaller proportion of the vermis than in wild-type
• when tamoxifen is given at E13.5 or E14.5 in adult the vermis has a foliation pattern that was a milder version than that observed in tamoxifen at 10.5 mutants
• when tamoxifen is given at E13.5 or E14.5 in adult posterior region lobule VIII is shifted posterior and fused with dorsal lobule IX.
• when tamoxifen is given at E13.5 or E14.5 in adult lobules I-V and VIII/IX of the vermis were present more laterally than normal tamoxifen at E13.5 or E14.5 in adult lobules I-III were fused into one lobule
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• absent at E18.5
|
|
• reduced in size at E18.5
|
|
• at E18.5, no cerebellum is present
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• delay in cerebellum foliation is observed in adult mice
|
|
• in E18.5 mutants, there is a general delay in fissure formation in vermis; less severe than in En2tm2Alj homozygotes
|
|
• vermis displays fused folia, and folia I, II, and III are smaller than normal in adults
|
|
• folium VIII is positioned between lobule VII and IX; folium VIII position is shifted posteriorly but less than in En2tm2Alj homozygotes
|
|
• reduced in size
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• about half of the expected number of mutants survive to adulthood
|
|
• reduced in size in surviving adults
|
|
• vermis displays fused folia, and folia I, II, and III are smaller than normal in adults
|
|
• subregion VIII (posterior vermis) is not present in adults
|
|
• in adults, reduced in overall size by one-third relative to controls
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• cerebellum and colliculi have normal morphology at E18.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no mutants are detected after birth
|
|
• absent at E18.5
|
|
• absent at E18.5
|
|
• at E18.5, no cerebellum is observed
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• die at birth
|
|
• decrease in the number of mesencephalic dopaminergic neurons
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 03/25/2025 MGI 6.24 |
|
|
|
||
