Phenotypes associated with this allele

• Allele Symbol: Crygs⁺
• Allele Name: wild type
• Allele ID: MGI:2158287
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Crygs^Opj/Crygs^+	involves: 102 * C3H/He * T STOCK	MGI:3584120
cx2	Hsf4^tm1Xyk/Hsf4^tm1Xyk Crygs^rncat/Crygs^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Kunming	MGI:3848445

Genotype
MGI:3584120

ht1

• Allelic Composition: Crygs^Opj/Crygs⁺
• Genetic Background: involves: 102 * C3H/He * T STOCK

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Progressive cataract development in Crygs^Opj/Crygs⁺ and Crygs^Opj/Crygs^Opj mice

vision/eye

abnormal lens fiber morphology ( J:34877 )

• poor secondary fiber cell junctions

disorganized secondary lens fibers ( J:21950 )

• described as a secondary lens fiber discontinuity

cataract ( J:34877 , J:68109 )

• opacity (J:34877)

• progressive with age and less severe than homozygote (J:68109)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 20 multiple types		DOID:0110240	OMIM:116100	J:34877 , J:68109

Genotype
MGI:3848445

cx2

• Allelic Composition: Hsf4^tm1Xyk/Hsf4^tm1Xyk; Crygs^rncat/Crygs⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Kunming

vision/eye

cataract ( J:149354 )

• cataracts develop in the posterior part of the lens by about 7 days of age