Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cryge+ wild type MGI:2158286 |
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| Summary |
12 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cataract | DOID:83 |
OMIM:601371 OMIM:PS116200 |
J:68708 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• bilateral
(J:6686)
• central cataracts, with opacity of the nucleus and perinuclear zone
(J:9528)
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• the granular opacity of the nucleus is surrounded by concentric, less opaque perinuclear zones
• the perinuclear layer may liquify
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• vacuoles are observed
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• with extracellular lens material and vacuoles in the cortical fibers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• dysplasia
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• dysplasia
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• total opacity
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all affected animals show a visible nuclear opacity
• Background Sensitivity: when heterozygous animals are derived from crosses to C3H/HeH mice, 53% of animals are affected by cataracts, showing mild diffuse opacities in the lens nucleus; when homozygous mutants are crossed to C3H/HeH mice, essentially all (98.2%) mice show the mild phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: when heterozygous animals are derived from crosses to C57BL/6 mice, only 28.5% of animals are affected by cataracts, showing mild diffuse opacities in the lens nucleus; this is likely due to incomplete penetrance of this phenotype on this background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the lens core is shifted anteriorly and a plaque of epithelial cells is found at the anterior pole
• the lens nucleus appears separated from the outer cortex
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• small vacuoles and swollen fiber cells are seen in various parts of the lens
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• dense nuclear and subcortical cataracts
• opacity is more severe in homozygotes compared to heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the wave of cell nuclei is not as well ordered as in wild-type mice
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• diffuse lenticular opacities that appear to contain homogeneously dispersed nucleic acids are seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fiber cell nuclei are only partially degraded and the wave of cell nuclei is not as well ordered as in wild-type mice
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• dense nuclear and subcortical cataracts
• opacity is more severe in homozygotes compared to heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lens completely degenerates by 30 days of age
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• lens is underdeveloped at birth
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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