Analysis Tools|
Allele Symbol Allele Name Allele ID |
Crygd+ wild type MGI:2158282 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• strong nuclear cataract; homogeneous milky opacity of the surrounding area, less severe than homozygotes at 12 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cataract 4 multiple types | DOID:0110234 |
OMIM:115700 |
J:78154 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the lens nucleus is completely shifted to the anterior epithelium and is highly vacuolated
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• the primary lens fiber cell have completely degenerated and the secondary fibers did not enlarge
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• degeneration of the primary lens fiber cells and failure of the secondary fiber cells to enlarge results in a very small lens
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the lens core is shifted anteriorly
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• small vacuoles and swollen fiber cells are seen in various parts of the lens
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• dense nuclear and subcortical cataracts
• opacity is more severe in homozygotes compared to heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the wave of cell nuclei is not as well ordered as in wild-type mice
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• diffuse lenticular opacities that appear to contain homogeneously dispersed nucleic acids are seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cataract 2 multiple types | DOID:0110235 |
OMIM:604307 |
J:60856 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• incomplete denucleation of lens fibers is observed as late as day 21 post birth
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• develop whole cataracts
• lens of 3 day old mice are resistant to ex vivo cold-induced cataract formation
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• slightly small lenses are observed
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/06/2026 MGI 6.24 |
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