Phenotypes associated with this allele

• Allele Symbol: Cdx2⁺
• Allele Name: wild type
• Allele ID: MGI:2158250
• Summary: 9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cdx2^tm1Mmt/Cdx2^+	B6.129X1-Cdx2^tm1Mmt	MGI:3715019
ht2	Cdx2^tm2.1Fbe/Cdx2^+	involves: 129P2/OlaHsd * BALB/cJ	MGI:5308977
ht3	Cdx2^tm1Fbe/Cdx2^+	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3613766
ht4	Cdx2^tm1Fbe/Cdx2^+	involves: 129S1/Sv * C57BL/6J	MGI:2175778
ht5	Cdx2^tm1Mmt/Cdx2^+	involves: 129X1/SvJ * C57BL/6	MGI:3715018
cn6	Cdx2^tm1.1Lhn/Cdx2^+ Tg(CAG-cre/ERT2)F34Fmr/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:4415157
cx7	Cdx2^tm1Mmt/Cdx2^+ Apc^tm1Mmt/Apc^+	B6.129-Cdx2^tm1Mmt Apc^tm1Mmt	MGI:3715020
cx8	Cdx2^tm1Fbe/Cdx2^+ Cdx4^tm1.1Jdes/Y	involves: 129 * C57BL/6 * CBA * FVB	MGI:3613767
cx9	Cdx2^tm1Fbe/Cdx2^+ Cdx4^tm1.1Jdes/Cdx4^+	involves: 129 * C57BL/6 * CBA * FVB	MGI:3613771

Genotype
MGI:3715019

ht1

• Allelic Composition: Cdx2^tm1Mmt/Cdx2⁺
• Genetic Background: B6.129X1-Cdx2^tm1Mmt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal colon morphology ( J:86737 )

• moderately increased anaphase bridge index

• accelerated transition from G1 to S phase

• increased DNA synthesis

• lower apoptotic rates

abnormal small intestine morphology ( J:86737 )

• moderately decreased anaphase bridge index

• decreased transition from G1 to S phase

• decreased DNA synthesis

• increased apoptotic rates

cellular

abnormal chromosome morphology ( J:86737 )

• moderately increased anaphase bridge index in the large intestine and decreased in the small intestine

abnormal cell cycle checkpoint function ( J:86737 )

• accelerated transition from G1 to S phase in the large intestine and decreased in the small intestine

• increased DNA synthesis in the large intestine and decreased in the small intestine

decreased apoptosis ( J:86737 )

• lower apoptotic rates in the large intestine

increased apoptosis ( J:86737 )

• in the small intestine

Genotype
MGI:5308977

ht2

• Allelic Composition: Cdx2^tm2.1Fbe/Cdx2⁺
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

digestive/alimentary system

intestine polyps ( J:179732 )

• organotypically normal gastric polyps in the paracaecal region in adults

Genotype
MGI:3613766

ht3

• Allelic Composition: Cdx2^tm1Fbe/Cdx2⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

embryo

abnormal placenta labyrinth morphology ( J:104372 )

• 6 of 62 embryos that do undergo normal chorioallantoic fusion display deficient placental labyrinth development at E10.5

failure of chorioallantoic fusion ( J:104372 )

• allantois of 3 of 54 heterozygotes has not fused with the chorion at E9.5

Genotype
MGI:2175778

ht4

• Allelic Composition: Cdx2^tm1Fbe/Cdx2⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J

growth/size/body

decreased body weight ( J:38772 )

skeleton

abnormal rib morphology ( J:38772 )

vertebral transformation ( J:38772 )

• anterior homeotic shift of the cervical and thoracic spine such as an 8th rib attached to the sternum, or the second rib attached to the sternum at the top of the manubrium together with the first rib

thoracic vertebral transformation ( J:38772 )

• T3 shows morphological features characteristic of the immediately cranial vertebrae in the wild-type

cervical vertebral transformation ( J:38772 )

• C6 and C7 show morphological features characteristic of the immediately cranial vertebrae in the wild-type

limbs/digits/tail

short tail ( J:38772 )

• 50-60% exhibit a short or kinked tail

kinked tail ( J:38772 )

• 50-60% exhibit a short or kinked tail

neoplasm

increased intestinal adenoma incidence ( J:38772 )

• presence of multiple adenomatous polyps at 12-28 weeks of age

• tumors are found predominately in the proximal colon and occasionally in the small intestine

increased colon adenoma incidence ( J:38772 )

• tumors are found predominately in the proximal colon

• largest tumors are pedunculated tubulovillous colonic adenomata

digestive/alimentary system

increased intestinal adenoma incidence ( J:38772 )

• presence of multiple adenomatous polyps at 12-28 weeks of age

• tumors are found predominately in the proximal colon and occasionally in the small intestine

increased colon adenoma incidence ( J:38772 )

• tumors are found predominately in the proximal colon

• largest tumors are pedunculated tubulovillous colonic adenomata

Genotype
MGI:3715018

ht5

• Allelic Composition: Cdx2^tm1Mmt/Cdx2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

growth/size/body

decreased body size ( J:47050 )

• runted

skeleton

abnormal rib morphology ( J:47050 )

• malformed

vertebral transformation ( J:47050 )

• anterior homeotic shift of vertebrae

digestive/alimentary system

abnormal cecum morphology ( J:47050 )

• numerous viliform structures aligned in rows

• epithelium containing enterocytes and a few goblet cells

• anteriorization of epithelium

abnormal colon morphology ( J:47050 )

• numerous viliform structures aligned in rows

• villi are structurally similar to those in ileum but extending from colonic type crypts

• epithelium containing enterocytes and a few goblet cells

• anteriorization of epithelium

colon polyps ( J:47050 )

• in proximal colon

• benign in nature

• up to 8 mm in diameter

• up to 10/mouse at 3 months of age

increased colon hamartoma incidence ( J:47050 )

• colonic polyps similar to hamartomas but lacking goblet or paneth cells

neoplasm

increased colon hamartoma incidence ( J:47050 )

• colonic polyps similar to hamartomas but lacking goblet or paneth cells

Genotype
MGI:4415157

cn6

• Allelic Composition: Cdx2^tm1.1Lhn/Cdx2⁺; Tg(CAG-cre/ERT2)F34Fmr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

limbs/digits/tail

sirenomelia ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5 and 100 mg/kg body weight retinoic acid at E8.5

short tail ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5 and 10 mg/kg body weight retinoic acid at E8.5

absent tail ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5 and 100 mg/kg body weight retinoic acid at E8.5

embryo

sirenomelia ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5 and 100 mg/kg body weight retinoic acid at E8.5

Genotype
MGI:3715020

cx7

• Allelic Composition: Cdx2^tm1Mmt/Cdx2⁺; Apc^tm1Mmt/Apc⁺
• Genetic Background: B6.129-Cdx2^tm1Mmt Apc^tm1Mmt

digestive/alimentary system

abnormal colon morphology ( J:86737 )

• increased anaphase bridge index

• accelerated transition from G1 to S phase

• increased DNA synthesis

• lower apoptotic rates

colon polyps ( J:86737 )

• increased in numbers relative to Apc^tm1Mmt

• mostly in the distal colon

abnormal small intestine morphology ( J:86737 )

• decreased anaphase bridge index

• decreased transition from G1 to S phase

• decreased DNA synthesis

• increased apoptotic rates

• significantly reduced number of polyps relative to Apc^tm1Mmt

cellular

abnormal chromosome morphology ( J:86737 )

• increased anaphase bridge index in the large intestine and decreased in the small intestine

abnormal cell cycle checkpoint function ( J:86737 )

• accelerated transition from G1 to S phase in the large intestine and decreased in the small intestine

• increased DNA synthesis in the large intestine and decreased in the small intestine

decreased apoptosis ( J:86737 )

• lower apoptotic rates in the large intestine

increased apoptosis ( J:86737 )

• in the small intestine

Genotype
MGI:3613767

cx8

• Allelic Composition: Cdx2^tm1Fbe/Cdx2⁺; Cdx4^tm1.1Jdes/Y
• Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:104372 )

♂ • die shortly after E10.5

growth/size/body

embryonic growth retardation ( J:104372 )

♂ • exhibit developmental retardation at E10.5

embryo

sirenomelia ( J:104372 )

♂ • truncation of embryonic structures posterior to the hindlimbs that results in a more anteriorly located tail bud

embryonic growth retardation ( J:104372 )

♂ • exhibit developmental retardation at E10.5

abnormal allantois morphology ( J:104372 )

♂ • allantoic endothelial cells often exhibit, to a variable extent, a poorer degree of primary vessel organization around the time of chorioallantoic fusion

abnormal placenta morphology ( J:104372 )

♂

abnormal placenta vasculature ( J:104372 )

♂ • at E10.5, maternal blood pools and embryonic blood vessels are widely separated

absent placenta hemotrichorial membrane ( J:104372 )

• the hemotrichorial membrane is almost completely absent

abnormal placenta labyrinth morphology ( J:104372 )

♂ • all embryos that do undergo chorioallantoic fusion display deficient placental labyrinth development at E10.5

♂ • fail to properly extend the allantoic vascular network into the chorionic ectoderm and do not develop a functional placental labyrinth

failure of chorioallantoic fusion ( J:104372 )

♂ • allantois of 7 of 35 mutants has not fused with the chorion at E9.5

skeleton

increased rib number ( J:104372 )

♂ • have 14 ribs due to the partial or complete bilateral rib attachment to V21

vertebral transformation ( J:104372 )

♂

thoracic vertebral transformation ( J:104372 )

♂ • 4 of 4 have the 8th pair of ribs attached to the sternum, indicating anterior transformation at the level of V15

lumbar vertebral transformation ( J:104372 )

♂ • 4 of 4 have a partial or complete rib attached to V21 bilaterally, at the position normally corresponding to the first lumbar vertebrae

homeostasis/metabolism

edema ( J:104372 )

♂ • thoracic edema at E10.5

limbs/digits/tail

sirenomelia ( J:104372 )

♂ • truncation of embryonic structures posterior to the hindlimbs that results in a more anteriorly located tail bud

cardiovascular system

abnormal placenta vasculature ( J:104372 )

♂ • at E10.5, maternal blood pools and embryonic blood vessels are widely separated

Genotype
MGI:3613771

cx9

• Allelic Composition: Cdx2^tm1Fbe/Cdx2⁺; Cdx4^tm1.1Jdes/Cdx4⁺
• Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

embryo

abnormal placenta labyrinth morphology ( J:104372 )

♀ • 2 of 11 embryos that do undergo normal chorioallantoic fusion display deficient placental labyrinth development at E10.5

failure of chorioallantoic fusion ( J:104372 )

♀ • allantois of 2 of 28 mutants has not fused with the chorion at E9.5