Phenotypes associated with this allele

• Allele Symbol: Otx2^tm3(otd)Asim
• Allele Name: targeted mutation 3, Antonio Simeone
• Allele ID: MGI:2157778
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm3(otd)Asim/Otx2^tm3(otd)Asim	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3796053

Genotype
MGI:3796053

hm1

• Allelic Composition: Otx2^tm3(otd)Asim/Otx2^tm3(otd)Asim
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal forebrain development ( J:72726 )

• moderately affected embryos display forebrain reduction

abnormal midbrain-hindbrain boundary development ( J:72726 )

• mildly affected embryos have variable anterior shift of presumptive midbrain-hindbrain boundary

exencephaly ( J:72726 )

• moderately affected embryos display exencephaly

growth/size/body

abnormal head morphology ( J:72726 )

• anterior defects are rescued compared to Otx2^tm4(otd)Asim homozygotes, but head and brain development are compromised at 10.5 dpc

• a low percentage exhibit a 'headless' (3.5%) or severe head (14%) phenotype, while >80% have mild or moderate phenotypes at 10.5 days post coitum (dpc)

acephaly ( J:72726 )

• a low percentage exhibit a 'headless' (3.5%) phenotype