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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apobtm4Sgy
targeted mutation 4, Stephen G Young
MGI:2157775
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Apobtm4Sgy/Apobtm4Sgy involves: 129S4/SvJae * C57BL/6 MGI:2662513
ht2
 		Apobtm2Sgy/Apobtm4Sgy involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:2672089


Genotype
MGI:2662513
hm1
Allelic
Composition		 Apobtm4Sgy/Apobtm4Sgy
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobtm4Sgy mutation (0 available); any Apob mutation (224 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:46549 )
• majority die in utero, with small percentage stillborn or dead perinatally

cardiovascular system
hemorrhage ( J:46549 )
• from brain into amniotic fluid

embryo

growth/size/body
decreased embryo size ( J:46549 )

liver/biliary system
herniated liver ( J:46549 )
• liver herniation into the umbilical cord

nervous system




Genotype
MGI:2672089
ht2
Allelic
Composition		 Apobtm2Sgy/Apobtm4Sgy
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobtm2Sgy mutation (6 available); any Apob mutation (224 available)
Apobtm4Sgy mutation (0 available); any Apob mutation (224 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory