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Allele Symbol Allele Name Allele ID |
Apoetm2(APOE*3)Mae targeted mutation 2, Nobuyo Maeda MGI:2157240 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice travel more in an open field during the habituation and acquisition phase than do Apoetm3(APOE*4)Mae mice
• particularly females
• females become slightly less active in testing phase
• no longer significantly more active in the retention phase and females clearly less active
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• aged (65-127 weeks) mutants fed a high-fat diet exhibit minor retinal pigment epithelium (RPE) changes such as RPE vacuolization
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• aged (65-127 weeks) mutants fed a high-fat diet exhibit minor retinal pigment epithelium (RPE) changes such as RPE vacuolization
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lesion size half that in Apoetm3(APOE*4)Mae after 3 months on an atherogenic diet
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• small plaques, typically an accumulation of several foam cells are seen in 4 of 11 females aged 10-12 months; considerably less severe than seen in Apoetm1(APOE)Mae homozygotes
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• after 12 weeks on a high fat/high cholesterol diet, develop significantly larger atherosclerotic plaques in the aortic sinus area than wild-type, indicating increased susceptibility to dietary-induced atherosclerosis
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• normal total cholesterol and triglyceride levels in fasted plasma when maintained on normal low fat chow diet, however show a difference in the distribution of plasma lipoproteins and apolipoprotein E
• beta-migrating lipoproteins (LDL) and plasma apoB100 levels are decreased and the apoE distribution is shifted from high density lipoproteins to larger lipoprotein particles
• the fractional catabolic rate of exogenously administered remnant particles in the beta-VLDL range without apoE is 6-fold slower than in wild-type
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• fasted mutants show an increase in pre-beta-migrating lipoproteins (VLDL) and absence of beta-migrating particles (LDL)
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• seen in fasted mice on a normal low fat chow diet
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• relative to Apoetm3(APOE*4)Mae regardless of diet
• decreased cholesterol/fatty acid ratio on a normal diet relative to Apoetm3(APOE*4)Mae
• decreased diameter of VLDL particles relative to Apoetm3(APOE*4)Mae
• increased clearance of Apoe deficient VLDL relative to Apoetm3(APOE*4)Mae
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• on a high fat/high cholesterol diet, show a 5-fold increase in total cholesterol compared to a 1.5-fold increase in wild-type, indicating increased susceptibility to dietary-induced hypercholesterolemia
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• relative to Apoetm3(APOE*4)Mae regardless of diet
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• on a high fat/high cholesterol diet, triglyceride levels are reduced to a smaller extent (18% vs. 50% in wild-type) than in wild-type
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• relative to Apoetm3(APOE*4)Mae regardless of diet
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• in the HDL fraction relative to Apoetm3(APOE*4)Mae regardless of diet
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• in response to lipopolysaccharide injection with a minimum after 3 hours
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• in response to lipopolysaccharide injection with a minimum after 1 hour
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• very little plaque development
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• significantly lower lipid levels on a normal fat diet
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• very little plaque development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region
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• plaque deposition in cortical parenchyma increased 20%
• reduced deposition in cerebral microvasculature
• microglia are tightly associated with parenchymal plaque amyloid
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• increased number of neuroreactive astrocytes in cortex
• decreased number of neuroreactive astrocytes in thalamic region
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• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region
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• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region
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• plaque deposition in cortical parenchyma increased 20%
• reduced deposition in cerebral microvasculature
• microglia are tightly associated with parenchymal plaque amyloid
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased levels of Amyloid beta 1-40 in cortical extracts at 3 months of age
• increased ratio of Amyloid beta 40:42 in cortical extracts at 3 months of age
• deposition delayed until after 12 months of age
• less plaque development than in Tg(APPSWE)2576Kha, Apoetm3(APOE*4Mae mice
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• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age
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• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age
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• increased levels of Amyloid beta 1-40 in cortical extracts at 3 months of age
• increased ratio of Amyloid beta 40:42 in cortical extracts at 3 months of age
• deposition delayed until after 12 months of age
• less plaque development than in Tg(APPSWE)2576Kha, Apoetm3(APOE*4Mae mice
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• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age
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• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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