Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-IAPP)RHFSoel
• Allele Name: transgene insertion RHF, Walter C Soeller
• Allele ID: MGI:2157065
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ins2-IAPP)RHFSoel/Tg(Ins2-IAPP)RHFSoel	involves: FVB/N	MGI:3771297

Genotype
MGI:3771297

tg1

• Allelic Composition: Tg(Ins2-IAPP)RHFSoel/Tg(Ins2-IAPP)RHFSoel
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased pancreatic beta cell apoptosis ( J:130022 )

• 6-fold increase in beta cell apoptosis

homeostasis/metabolism

decreased insulin secretion ( J:130022 )

• despite hyperglycemia, mice exhibit decreased plasma insulin levels compared to Tg(Iapp-Iapp)3Wcs homozygotes implying defective insulin secretion

hyperglycemia ( J:130022 )

decreased circulating insulin level ( J:130022 )

endocrine/exocrine glands

increased pancreatic beta cell apoptosis ( J:130022 )

• 6-fold increase in beta cell apoptosis

abnormal pancreatic islet morphology ( J:130022 )

• islet cells exhibit an increased expression of the endoplasmic reticulum (ER) chaperon Hspa5 and ER stress markers

decreased pancreatic beta cell mass ( J:130022 )

• at 10 weeks, beta cell mass is decreased 48% compared to in wild-type mice due to a 6-fold increase in beta cell apoptosis

decreased insulin secretion ( J:130022 )

• despite hyperglycemia, mice exhibit decreased plasma insulin levels compared to Tg(Iapp-Iapp)3Wcs homozygotes implying defective insulin secretion

immune system

increased susceptibility to autoimmune diabetes ( J:130022 )

• mice develop diabetes at 10 weeks of age