Phenotypes associated with this allele

• Allele Symbol: Pax6^4Neu
• Allele Name: 4, Neuherberg
• Allele ID: MGI:2156741
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax6^4Neu/Pax6^4Neu	either: (involves: 102 * C3H) or (involves: C3H)	MGI:2173411
hm2	Pax6^4Neu/Pax6^4Neu	involves: C3HeB/FeJ	MGI:3521823
ht3	Pax6^4Neu/Pax6^+	either: (involves: 102 * C3H) or (involves: C3H)	MGI:3590308

Genotype
MGI:2173411

hm1

• Allelic Composition: Pax6^4Neu/Pax6^4Neu
• Genetic Background: either: (involves: 102 * C3H) or (involves: C3H)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:73625 )

• survive 24-36 hours after birth

vision/eye

anophthalmia ( J:73625 )

• occasionally with a distinct optic pit and underlying pigmentation

craniofacial

abnormal craniofacial development ( J:73625 )

• hyperplasia of cartilaginous parts of nasal anlage and reduced nasal cavities

abnormal lateral nasal prominence morphology ( J:73625 )

• reduced lateral nasal processes

abnormal medial nasal prominence morphology ( J:73625 )

• reduced medial nasal processes

Genotype
MGI:3521823

hm2

• Allelic Composition: Pax6^4Neu/Pax6^4Neu
• Genetic Background: involves: C3HeB/FeJ

nervous system

abnormal telencephalon morphology ( J:94457 )

• some alteration of the dorso-ventral telencephalic boundary, however no decrease in the number of neurons in the cerebral cortex or increase in the subventricular zone precursors, indicating that the homeodomain is not required for neurogenesis in the cortex

Genotype
MGI:3590308

ht3

• Allelic Composition: Pax6^4Neu/Pax6⁺
• Genetic Background: either: (involves: 102 * C3H) or (involves: C3H)

vision/eye

abnormal iris morphology ( J:73625 )

• abnormalities

irregularly shaped pupil ( J:73625 )

anterior iris synechia ( J:63651 )

cataract ( J:63651 )

anterior polar cataract ( J:73625 )

• anterior polar opacity very moderate

microphthalmia ( J:63651 , J:73625 )

• but very slight (J:73625)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peters anomaly		DOID:0060673	OMIM:604229	J:73625