Analysis Tools
endocrine/exocrine glands
 |
• terminal end buds (TEB) in 5 week old females lack well-defined lumens
• 86.6% of wild-type TEBs have well-defined lumens compared to just 4.4% of controls
• these TEBs are larger in size and contain an inner cell population that is composed of an unorganized epithelial mass and scattered squamous cell clusters
• mutant TEBs are associated with 10-fold less apoptosis than controls
• ducts also have defects in clearing of inner cells at 5 weeks of age
|
|
|
• ducts of 5-week old mammary glands lack well defined lumens compared to controls
• an inner cell population that is composed of an unorganized epithelial mass and scattered squamous cell clusters
• squamous cell clusters lack adhesion to the epithelial cells of the duct may represent a population of cells undergoing squamous differentiation
• these squamous cells express keratin and some other epithelial markers
• at 6-7 weeks, the inner cell population begins dying off in a caspase-independent manner
• by 8 weeks ducts are hollowed and indistinguishable from wild-type controls
|
integument
|
|
• terminal end buds (TEB) in 5 week old females lack well-defined lumens
• 86.6% of wild-type TEBs have well-defined lumens compared to just 4.4% of controls
• these TEBs are larger in size and contain an inner cell population that is composed of an unorganized epithelial mass and scattered squamous cell clusters
• mutant TEBs are associated with 10-fold less apoptosis than controls
• ducts also have defects in clearing of inner cells at 5 weeks of age
|
|
|
• ducts of 5-week old mammary glands lack well defined lumens compared to controls
• an inner cell population that is composed of an unorganized epithelial mass and scattered squamous cell clusters
• squamous cell clusters lack adhesion to the epithelial cells of the duct may represent a population of cells undergoing squamous differentiation
• these squamous cells express keratin and some other epithelial markers
• at 6-7 weeks, the inner cell population begins dying off in a caspase-independent manner
• by 8 weeks ducts are hollowed and indistinguishable from wild-type controls
|
