Phenotypes associated with this allele

• Allele Symbol: Cdc42^tm1Fwa
• Allele Name: targeted mutation 1, Fredrick W Alt
• Allele ID: MGI:2156460
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdc42^tm1Fwa/Cdc42^tm1Fwa	involves: 129S6/SvEvTac	MGI:3848920

Genotype
MGI:3848920

hm1

• Allelic Composition: Cdc42^tm1Fwa/Cdc42^tm1Fwa
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:63261 )

• no homozygous embryos at E7.5

• mostly degenerated at E6.5

• blastocysts visibly normal at E3.5

embryo

decreased embryo size ( J:63261 )

• embryos at E5.5 are smaller than normal

absent embryonic epiblast ( J:63261 )

• embryonic primary ectoderm largely lacking at E5.5

disorganized embryonic tissue ( J:63261 )

• at E5.5

cellular

abnormal actin cytoskeleton morphology ( J:63261 )

• actin structures in homozygous ES cells are diffuse and disorganized

growth/size/body

decreased embryo size ( J:63261 )

• embryos at E5.5 are smaller than normal