All Phenotypes Epha4<Gt(PST038)Byg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Epha4^{Gt(PST038)Byg}
gene trap PST038, BayGenomics
MGI:2156201

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg}	involves: 129P2/OlaHsd	MGI:3662910
hm2	Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg}	involves: 129P2/OlaHsd * C57BL/6J	MGI:3662913
ht3	Epha4^{Gt(PST038)Byg}/Epha4^tm1Kldr	involves: 129P2/OlaHsd	MGI:3823255
cx4	Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Ret^tm1.1Kln/Ret^tm1.1Kln	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J	MGI:3662909

Allelic Composition	Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg}
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4^{Gt(PST038)Byg} mutation (1 available); any Epha4 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:110955 )

• majority of E11.5 embryos display a Category II intermediate phenotype; the peroneal nerve is significantly shorter than in controls; at E12.5 mutants show a mild reduction of peroneal axons while Ret-null mice at E12.5 show an intermediate phenotype

Allelic Composition	Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4^{Gt(PST038)Byg} mutation (1 available); any Epha4 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal gait ( J:67920 , J:70273 )

• mice exhibit a hopping kangaroo gait (J:67920)

nervous system

abnormal axon guidance ( J:67920 , J:70273 )

• mice have guidance defects in the corticospinal tract and in the anterior commissure (J:67920)

abnormal anterior commissure morphology ( J:67920 )

• mice have guidance defects in the anterior commissure

abnormal corticospinal tract morphology ( J:67920 )

• mice have guidance defects in the corticospinal tract

cellular

abnormal axon guidance ( J:67920 , J:70273 )

• mice have guidance defects in the corticospinal tract and in the anterior commissure (J:67920)

Allelic Composition	Epha4^{Gt(PST038)Byg}/Epha4^tm1Kldr
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4^{Gt(PST038)Byg} mutation (1 available); any Epha4 mutation (66 available)
Epha4^tm1Kldr mutation (0 available); any Epha4 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron innervation pattern ( J:82479 )

• spinal cord neurons that normally express Epha4 aberrantly cross the spinal cord midline to the contralateral side

abnormal corticospinal tract morphology ( J:82479 )

• spinal cord neurons that normally express Epha4 aberrantly cross the spinal cord midline to the contralateral side

Allelic Composition	Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Ret^tm1.1Kln/Ret^tm1.1Kln
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4^{Gt(PST038)Byg} mutation (1 available); any Epha4 mutation (66 available)
Ret^tm1.1Kln mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:110955 )

• mice show severe axon guidance defects

• all embryos have severely affected, Category III phenotypes; peroneal nerve is severely shortened and often defasciculated

abnormal innervation pattern to muscle ( J:110955 )

cellular

abnormal axon guidance ( J:110955 )

• mice show severe axon guidance defects

• all embryos have severely affected, Category III phenotypes; peroneal nerve is severely shortened and often defasciculated

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23