All Phenotypes Plcg1<tm1Ine> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plcg1^tm1Ine
targeted mutation 1, Izumi Negishi
MGI:2155982

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plcg1^tm1Ine/Plcg1^tm1Ine	involves: 129P2/OlaHsd	MGI:3629731

Allelic Composition	Plcg1^tm1Ine/Plcg1^tm1Ine
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg1^tm1Ine mutation (0 available); any Plcg1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• homozygotes die at E8.5-E9.5

embryo

abnormal embryonic hematopoiesis ( J:73254 )

• macroscopically, E9.5 homozygotes exhibit extremely reduced hematopoiesis relative to wild-type embryos

• in vitro, mutant ES cells exhibit significantly reduced differentiation into hematopoietic cells relative to wild-type ES cells

hematopoietic system

abnormal embryonic hematopoiesis ( J:73254 )

• macroscopically, E9.5 homozygotes exhibit extremely reduced hematopoiesis relative to wild-type embryos

• in vitro, mutant ES cells exhibit significantly reduced differentiation into hematopoietic cells relative to wild-type ES cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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