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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sles1NZW
NZW
MGI:2155791
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sles1NZW/Sles1NZW involves: C57BL/6 * NZW MGI:2677503
ht2
 		Sles1C57BL/6/Sles1NZW involves: C57BL/6 * NZW MGI:2677501
cx3
 		Sle1NZW/Sle1NZW
Sles1NZW/Sles1NZW 		involves: C57BL/6 * NZW MGI:3604961


Genotype
MGI:2677503
hm1
Allelic
Composition		 Sles1NZW/Sles1NZW
Genetic
Background		 involves: C57BL/6 * NZW
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to systemic lupus erythematosus ( J:57246 )
• resistance to systemic lupus erythematosus




Genotype
MGI:2677501
ht2
Allelic
Composition		 Sles1C57BL/6/Sles1NZW
Genetic
Background		 involves: C57BL/6 * NZW
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:57246 )
• susceptibility to systemic lupus erythematosus




Genotype
MGI:3604961
cx3
Allelic
Composition		 Sle1NZW/Sle1NZW
Sles1NZW/Sles1NZW
Genetic
Background		 involves: C57BL/6 * NZW
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sle1NZW mutation (0 available); any Sle1 mutation (2 available)
Sles1NZW mutation (0 available); any Sles1 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:100678 )
• suppression of CD3+ T cell activation
• suppression of CD69 cell surface expression
decreased susceptibility to systemic lupus erythematosus ( J:100678 )
• suppression of anti-nuclear antibody production

hematopoietic system
abnormal T cell physiology ( J:100678 )
• suppression of CD3+ T cell activation
• suppression of CD69 cell surface expression




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory