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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gjb2tm1Kwi
targeted mutation 1, Klaus Willecke
MGI:2155739
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gjb2tm1Kwi/Gjb2tm1Kwi involves: 129P2/OlaHsd * C57BL/6 MGI:3588778


Genotype
MGI:3588778
hm1
Allelic
Composition		 Gjb2tm1Kwi/Gjb2tm1Kwi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjb2tm1Kwi mutation (1 available); any Gjb2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Small size of Gjb2tm1Kwi/Gjb2tm1Kwi embryos

mortality/aging

embryo
abnormal placental labyrinth vasculature morphology ( J:46665 )
• fewer embryonic blood vessels
decreased embryo size ( J:46665 )
• significantly smaller at E10.5 than wild-type
decreased placental labyrinth size ( J:46665 )
• appears smaller than in wild-type
abnormal placenta development ( J:46665 )
• retarded placental development at E10.5
abnormal placental transport ( J:46665 )
• 60% decrease in transplacental uptake of 3-O-[14C]methylglucose compared to wild-type

growth/size/body
decreased embryo size ( J:46665 )
• significantly smaller at E10.5 than wild-type

cardiovascular system
abnormal placental labyrinth vasculature morphology ( J:46665 )
• fewer embryonic blood vessels




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory