Phenotypes associated with this allele
Allelic
Composition |
Snrpntm2Cbr/Snrpn+
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Genetic
Background |
either: B6.Cg-Snrpntm2Cbr or (involves: 129S1/Sv * C57BL/6J * DBA/2J) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrpntm2Cbr mutation
(1 available);
any
Snrpn mutation
(23 available)
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mortality/aging
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• all pups die within 7 days of birth
• Background Sensitivity: survival is impaired compared to heterozygous pups from crosses of heterozygous males to wild-type females of the 129S1/Sv, BALB/c, C3H/HeJ, or FVB/NJ strains
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cellular
Allelic
Composition |
Snrpntm2Cbr/Snrpn+
|
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Genetic
Background |
either: (involves: 129S1/Sv * C57BL/6J) or (involves: 129S1/Sv * BALB/c * C57BL/6J) or (involves: 129S1/Sv * C3H/HeJ * C57BL/6J) or (involves: 129S1/Sv * C57BL/6J * FVB/NJ) |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrpntm2Cbr mutation
(1 available);
any
Snrpn mutation
(23 available)
|
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mortality/aging
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• most heterozygous pups die within 14 days of birth but with removal of all but 1 wild-type littermate some survive to adulthood and are fertile
• Background Sensitivity: all heterozygous pups die within 7 days of birth when a heterozygous male on a 129S1/Sv background is crossed to a wild-type female of the C57BL/6J strain unlike the reciprocal cross where some heterozygous pups survive
• Background Sensitivity: survival is improved compared to heterozygous pups from crosses of heterozygous males (on a C57BL/6J background) to wild-type females of the C57BL/6J or DBA/2J strains
• Background Sensitivity: if the wild-type female crossed to a heterozygous male is an F1 cross of C57BL/6J and either C3H/HeJ, or FVB/NJ survival of heterozygous pups is impaired compared to crosses where the female is inbred C3H/HeJ, or FVB/NJ
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growth/size/body
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• as adults surviving pups are significantly smaller than wild-type littermates and never become obese
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reproductive system
|
N |
• survivng heterozygotes are fertile
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cellular
Allelic
Composition |
Snrpntm2Cbr/Snrpn+
|
|
Genetic
Background |
involves: 129S1/Sv * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrpntm2Cbr mutation
(1 available);
any
Snrpn mutation
(23 available)
|
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mortality/aging
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• 72% of heterozygotes die within 48 hours of birth with none surviving past 7 days of age
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• less than 5% of mice heterozygous for the paternally inherited deletion allele alone survive to weaning
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behavior/neurological
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• heterozygotes are capable of suckling but consistently have less milk in their stomachs compared to wild-type littermates
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• mice that survive past 2 days display weakness
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• heterozygotes are unable to support themselves on their hind feet and instead rest on their knees
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growth/size/body
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• on the day of birth heterozygotes appear normal but weigh about 20% less than wild-type littermates
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• mice that survive past 2 days fail to maintain normal growth rates
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homeostasis/metabolism
reproductive system
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N |
• no genital or gonadal hypoplasia is seen at birth
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cellular
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• in J:47318 all heterozygotes carry a paternally inherited mutant allele
(J:47318)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrpntm1Rsnk mutation
(0 available);
any
Snrpn mutation
(23 available)
Snrpntm2Cbr mutation
(1 available);
any
Snrpn mutation
(23 available)
|
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growth/size/body
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• mice still display a growth deficiency with males and females weighing 58% and 61% that of wild-type littermates, respectively, at 3 weeks of age
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cellular
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• when the knockin allele is maternally inherited and the deletion allele is paternally inherited about 98% of these mice survive to weaning compared to less than 5% of mice heterozygous for the paternally inherited deletion allele alone
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Analysis Tools