All Phenotypes Cd3e<tm1Mal> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd3e^tm1Mal
targeted mutation 1, Bernard Malissen
MGI:2155092

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd3e^tm1Mal/Cd3e^tm1Mal	C57BL/6-Cd3e^tm1Mal	MGI:3759843
hm2	Cd3e^tm1Mal/Cd3e^tm1Mal	involves: C57BL/6	MGI:2653630
cx3	Cd3e^tm1Mal/Cd3e^tm1Mal Lat^tm1.1Mal/Lat^tm1.1Mal	involves: 129S2/SvPas * C57BL/6	MGI:3770646
cx4	Cd3e^tm1Mal/Cd3e^tm1Mal Tg(Tcrb-TCF3/PBX1)23Gusa/0	involves: C3H * C57BL/6 * C57BL/6J	MGI:5638106
cx5	Cd3e^tm1Mal/Cd3e^tm1Mal Nlrp1a^Neut1/Nlrp1a^Neut1	involves: C57BL/6	MGI:5474289

Allelic Composition	Cd3e^tm1Mal/Cd3e^tm1Mal
Genetic Background	C57BL/6-Cd3e^tm1Mal

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1Mal mutation (4 available); any Cd3e mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:125748 )

• mice die of a wasting autoimmune disease starting 15 weeks after transfer of nave wild-type CD4 T cells

immune system

abnormal double-negative T cell morphology ( J:81133 )

• proportion of and absolute number of CD117++ double negative (CD44+CD25-) cells among thymocytes is reduced

arrested T cell differentiation ( J:81133 )

• severe block in T cell development

absent T cells ( J:131351 )

• T cells are absent in these mice

abnormal B cell morphology ( J:81133 )

• with increasing age, the number of thymic B cells remains constant, however proportion of pro/pre-B cells is decreased with time

abnormal regulatory T cell physiology ( J:125748 )

• mice exhibit symptoms of an autoimmune disorder starting 12 weeks after transfer of nave wild-type CD4 T Cells

• however, mice fail to develop signs of wasting disease after transfer of wild-type CD25-positive CD4 T cells

hematopoietic system

abnormal double-negative T cell morphology ( J:81133 )

• proportion of and absolute number of CD117++ double negative (CD44+CD25-) cells among thymocytes is reduced

arrested T cell differentiation ( J:81133 )

• severe block in T cell development

absent T cells ( J:131351 )

• T cells are absent in these mice

abnormal B cell morphology ( J:81133 )

• with increasing age, the number of thymic B cells remains constant, however proportion of pro/pre-B cells is decreased with time

abnormal regulatory T cell physiology ( J:125748 )

• mice exhibit symptoms of an autoimmune disorder starting 12 weeks after transfer of nave wild-type CD4 T Cells

• however, mice fail to develop signs of wasting disease after transfer of wild-type CD25-positive CD4 T cells

Allelic Composition	Cd3e^tm1Mal/Cd3e^tm1Mal
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1Mal mutation (4 available); any Cd3e mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

arrested T cell differentiation ( J:77098 )

• T cells are arrested at the double negative stage

absent CD4-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

absent CD8-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

hematopoietic system

arrested T cell differentiation ( J:77098 )

• T cells are arrested at the double negative stage

absent CD4-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

absent CD8-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

Allelic Composition	Cd3e^tm1Mal/Cd3e^tm1Mal Lat^tm1.1Mal/Lat^tm1.1Mal
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1Mal mutation (4 available); any Cd3e mutation (47 available)
Lat^tm1.1Mal mutation (0 available); any Lat mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:77098 )

N	• pathological B cells of Lat^tm1Mal homozygotes are absent in these mice

arrested T cell differentiation ( J:77098 )

• T cells are arrested at the double negative stage

absent CD4-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

absent CD8-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

hematopoietic system

arrested T cell differentiation ( J:77098 )

• T cells are arrested at the double negative stage

absent CD4-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

absent CD8-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

Allelic Composition	Cd3e^tm1Mal/Cd3e^tm1Mal Tg(Tcrb-TCF3/PBX1)23Gusa/0
Genetic Background	involves: C3H * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1Mal mutation (4 available); any Cd3e mutation (47 available)
Tg(Tcrb-TCF3/PBX1)23Gusa mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased leukemia incidence ( J:95693 )

• leukemia tumor development penetrance is 87%

• mice intraperitonally injected with MMLV show accelerated pre-B-cell leukemia formation compared to controls

increased acute lymphoblastic leukemia incidence ( J:95693 )

• 40% of mice develop B-cell acute lymphoblastic leukemia

• however, mice do not develop T-cell acute lymphoblastic leukemia, myeloid leukemia, or mixed B-cell/myeloid leukemia

• B-cell leukemia development is accelerated compared to single Tg(Tcrb-TCF3/PBX1)23Gusa transgenic mice

• B-cell tumors are B220+/CD43-/CD19+/IgM-/Pax5+, indicating a pre-B-cell phenotype, and contain IgH chain rearrangements, mostly of the kappa light chain

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute leukemia		DOID:12603	OMIM:308960	J:95693

Allelic Composition	Cd3e^tm1Mal/Cd3e^tm1Mal Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1Mal mutation (4 available); any Cd3e mutation (47 available)
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased neutrophil cell number ( J:191055 )

skin inflammation ( J:191055 )

• neutrophil infiltration of the dermis

increased susceptibility to infection induced morbidity/mortality ( J:191055 )

• reduction in disease free survival

mortality/aging

increased susceptibility to infection induced morbidity/mortality ( J:191055 )

• reduction in disease free survival

hematopoietic system

increased neutrophil cell number ( J:191055 )

integument

skin inflammation ( J:191055 )

• neutrophil infiltration of the dermis

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