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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgb1tm1Son
targeted mutation 1, Arnoud Sonnenberg
MGI:2154543
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itgb1tm1Son/Itgb1tm1Son either: 129P2/OlaHsd-Itgb1tm1Son or (involves: 129P2/OlaHsd * FVB) MGI:3703916


Genotype
MGI:3703916
hm1
Allelic
Composition		 Itgb1tm1Son/Itgb1tm1Son
Genetic
Background		 either: 129P2/OlaHsd-Itgb1tm1Son or (involves: 129P2/OlaHsd * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm1Son mutation (0 available); any Itgb1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiovascular system physiology ( J:47279 )
• males, but not females, show a 6-fold increase in ANP mRNA and a 25% increase in beta-MHC protein levels, indicating a ventricular dysfunction despite the lack of any histological abnormalities or hypertrophic responses

muscle
muscle phenotype ( J:47279 )
N
• mutants do not exhibit any abnormalities in muscle morphology




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory