Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcc1tm1Rhs mutation
(0 available);
any
Smarcc1 mutation
(69 available)
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mortality/aging
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• embryos die at the peri-implantation stage; embryos undergo normal hatching and partial outgrowth in culture
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embryo
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• no visible endoderm layer
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• a few dispersed cells were noted
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Allelic
Composition |
Smarcc1tm1Rhs/Smarcc1+
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Genetic
Background |
involves: 129S4/SvJaeSor * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcc1tm1Rhs mutation
(0 available);
any
Smarcc1 mutation
(69 available)
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nervous system
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• ectopic proliferating and differentiating cells were noted in the upper posterior region, and the cells were reduced in number in the telencephalic striatum region
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• extensive malformations in embryos exhibiting exencephaly; expansion of the corpus striatum mediale
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• epithelia were located below the thalamus; ganglionic eminence appeared rotated towards the midline
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• 20% of heterozygous embryos exhibit exencephaly
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embryo
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• in some embryos exhibit failure of neural fold elevation resulting in failure of neural plate closing and an abnormal brain structure
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• ectopic proliferating and differentiating cells were noted in the upper posterior region, and the cells were reduced in number in the telencephalic striatum region
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Analysis Tools