Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ttpa+ wild type MGI:2154478 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• chow-fed heterozygotes exhibit a ~50% reduction of alpha-tocopherol levels in plasma and most tissues
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| familial isolated deficiency of vitamin E | DOID:0090028 |
OMIM:277460 |
J:66419 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when fed a normal diet (36 mg of alpha-tocopherol/kg diet), heterozygous null mice displayed a 50% reduction in plasma vitamin E (alpha-tocopherol) concentration relative to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• chow-fed mice heterozygous for Ttpatm1Far and homozygous for Apoetm1Unc show a 24% reduction of plasma alpha-tocopherol levels relative to single Apoetm1Unc homozygotes
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• at 30 weeks of age, chow-fed female mice heterozygous for Ttpatm1Far and homozygous for Apoetm1Unc have 13% larger atherosclerotic lesions in the aortic arch region relative to single Apoetm1Unc homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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