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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		T(2;10)67Gso
reciprocal translocation, Chr 2 and 10, Generoso 67
MGI:2154472
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		T(2;10)67Gso/T(2;10)67Gso involves: 101 * C3H * C3H/Rl * C57BL/RlGso * SEC/RlGso MGI:3583134
ht2
 		T(2;10)67Gso/+ involves: 101 * C3H * C3H/Rl * C57BL/RlGso * SEC/RlGso MGI:3583139
cx3
 		Bicc1jcpk/T(2;10)67Gso involves: 101 * C3H * C3H/Rl * C57BL/6 * C57BL/RlGso * SEC/RlGso MGI:3583140
cx4
 		Bicc1jcpk-67Gso/Bicc1jcpk-67Gso
T(2;10)67Gso/T(2;10)67Gso 		involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso MGI:4821954


Genotype
MGI:3583134
hm1
Allelic
Composition		 T(2;10)67Gso/T(2;10)67Gso
Genetic
Background		 involves: 101 * C3H * C3H/Rl * C57BL/RlGso * SEC/RlGso
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:75799 )
• most of those that survive the first day of life die by 3-4 days of age
neonatal lethality, incomplete penetrance ( J:75799 )
• many homozygotes die immediately after birth

renal/urinary system
kidney cyst ( J:75799 )
• elongated cysts that extend radially from the cortex towards the medullary pyramid
• collecting tubules within the cortex are elongated and dilated with cysts which are lined with cuboidal epithelium
enlarged kidney ( J:75799 )
• kidneys are bilaterally enlarged and pale

liver/biliary system
biliary cyst ( J:75799 )
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen
• cysts are lined with a single layer of low columnar to cuboidal cells
jaundice ( J:75799 )
• most homozygotes turn a yellow-orange color before death

growth/size/body
biliary cyst ( J:75799 )
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen
• cysts are lined with a single layer of low columnar to cuboidal cells
decreased birth body size ( J:75799 )
• homozytgotes are smaller than unaffected littermates at birth
kidney cyst ( J:75799 )
• elongated cysts that extend radially from the cortex towards the medullary pyramid
• collecting tubules within the cortex are elongated and dilated with cysts which are lined with cuboidal epithelium
distended abdomen ( J:75799 )
• seen at 1-3 days of age
enlarged kidney ( J:75799 )
• kidneys are bilaterally enlarged and pale

behavior/neurological
weakness ( J:75799 )
• homozytgotes are weaker than unaffected littermates at birth

endocrine/exocrine glands
biliary cyst ( J:75799 )
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen
• cysts are lined with a single layer of low columnar to cuboidal cells

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autosomal recessive polycystic kidney disease DOID:0110861 OMIM:263200
 J:75799




Genotype
MGI:3583139
ht2
Allelic
Composition		 T(2;10)67Gso/+
Genetic
Background		 involves: 101 * C3H * C3H/Rl * C57BL/RlGso * SEC/RlGso
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced fertility ( J:75799 )
• males and females are semi-sterile




Genotype
MGI:3583140
cx3
Allelic
Composition		 Bicc1jcpk/T(2;10)67Gso
Genetic
Background		 involves: 101 * C3H * C3H/Rl * C57BL/6 * C57BL/RlGso * SEC/RlGso
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicc1jcpk mutation (0 available); any Bicc1 mutation (65 available)
T(2;10)67Gso mutation (0 available); any T(2;10)67Gso mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
polycystic kidney ( J:75799 )
• polycystic kidneys seen by 10 days of age

growth/size/body
polycystic kidney ( J:75799 )
• polycystic kidneys seen by 10 days of age
distended abdomen ( J:75799 )
enlarged kidney ( J:75799 )




Genotype
MGI:4821954
cx4
Allelic
Composition		 Bicc1jcpk-67Gso/Bicc1jcpk-67Gso
T(2;10)67Gso/T(2;10)67Gso
Genetic
Background		 involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicc1jcpk-67Gso mutation (0 available); any Bicc1 mutation (65 available)
T(2;10)67Gso mutation (0 available); any T(2;10)67Gso mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:75799 )
• many homozygotes die immediately after birth
• earliest onset in mice homozygous for this allele compared with mice homozygous for Bicc1jcpk or Bicc1jcpk-bpk
postnatal lethality, incomplete penetrance ( J:75799 )
• most of those that survive the first day of life die by 3-4 days of age

behavior/neurological
weakness ( J:75799 )
• homozytgotes are weaker than unaffected littermates at birth

endocrine/exocrine glands
abnormal biliary ductule morphology ( J:75799 )
• ducts are increased in number and dilated, extending into the hepatic lobes
abnormal interlobular bile duct morphology ( J:75799 )
• no normal interlobular ducts are seen
biliary cyst ( J:75799 )
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen
• cysts are lined with a single layer of low columnar to cuboidal cells

growth/size/body
biliary cyst ( J:75799 )
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen
• cysts are lined with a single layer of low columnar to cuboidal cells
decreased birth body size ( J:75799 )
• homozytgotes are smaller than unaffected littermates at birth
kidney cyst ( J:75799 )
• narrow elongated cysts extend radially from the cortex toward the medullary pyramid
• cortical collecting tubules are elongated, lined with cuboidal epithelium and dilated by cysts
• collecting tubules and glomeruli seem compressed by cysts
distended abdomen ( J:75799 )
• seen at 1-3 days of age
enlarged kidney ( J:75799 )
• bilateral enlargement

liver/biliary system
biliary cyst ( J:75799 )
• cysts are lined with a single layer of low columnar to cuboidal cells
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen
abnormal liver morphology ( J:75799 )
• most extreme in mice homozygous for this allele compared with mice homozygous for Bicc1jcpk or Bicc1jcpk-bpk
abnormal biliary ductule morphology ( J:75799 )
• ducts are increased in number and dilated, extending into the hepatic lobes
abnormal liver parenchyma morphology ( J:75799 )
• normal parenchyma is lacking
abnormal interlobular bile duct morphology ( J:75799 )
• no normal interlobular ducts are seen
jaundice ( J:75799 )
• most homozygotes turn a yellow-orange color before death

renal/urinary system
abnormal kidney morphology ( J:75799 )
• pale and enlarged
kidney cyst ( J:75799 )
• narrow elongated cysts extend radially from the cortex toward the medullary pyramid
• cortical collecting tubules are elongated, lined with cuboidal epithelium and dilated by cysts
• collecting tubules and glomeruli seem compressed by cysts
enlarged kidney ( J:75799 )
• bilateral enlargement




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory