Phenotypes associated with this allele

• Allele Symbol: Pex5^tm1Baes
• Allele Name: targeted mutation 1, Myriam Baes
• Allele ID: MGI:2154454
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pex5^tm1Baes/Pex5^tm1Baes	involves: 129S1/Sv * 129X1/SvJ	MGI:2668630

Genotype
MGI:2668630

hm1

• Allelic Composition: Pex5^tm1Baes/Pex5^tm1Baes
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:42719 )

• survival is limited to 3 to 4 days

digestive/alimentary system

delayed intestine development ( J:42719 )

• examined at E18.5 and P0

embryo

embryonic growth retardation ( J:42719 )

• as examined at E13.5

growth/size/body

embryonic growth retardation ( J:42719 )

• as examined at E13.5

decreased body weight ( J:42719 )

• 30% body weight reduction at birth compared to littermates

liver/biliary system

abnormal liver morphology ( J:42719 )

• abnormal mitochondrial structure, autophagic vacuoles, accumulation of lipids and increased number of macrophages; absence of peroxisomes in hepatocytes

muscle

muscle weakness ( J:42719 )

• hypotonic, unable to support their weight

renal/urinary system

abnormal kidney morphology ( J:42719 )

• autophagic vacuoles, and increased number of macrophages; absence of peroxisomes in renal epithelial cells

delayed kidney development ( J:42719 )

• examined at E18.5 and P0

respiratory system

respiratory distress ( J:42719 )

• noted in some neonates, variable onset and severity

nervous system

delayed brain development ( J:42719 )

• reduced thickness of the neocortical plate examined at P0.5

abnormal cerebral cortex morphology ( J:42719 )

• reduced thickness of cortex