Phenotypes associated with this allele
Allelic Composition |
Ascl2tm1Alj/Ascl2tm1Alj
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Genetic Background |
either: (involves: 129) or (involves: 129 * CD-1) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl2tm1Alj mutation
(0 available);
any
Ascl2 mutation
(15 available)
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mortality/aging
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• embryos die by E9.5- E10.5
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embryo
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• lacked the vascular organization of normal placentas
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• normal chorio-allantoic fusion, but chorion remained compact
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• ectopic secondary giant cells: present and formed multiple cell layers
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cardiovascular system
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• lacked the vascular organization of normal placentas
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl2tm1Alj mutation
(0 available);
any
Ascl2 mutation
(15 available)
|
|
|
mortality/aging
|
• embryos die between 9.5 and 10.5 days post-coitum from placenta failure
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embryo
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• chorion membrane is underdeveloped at time of embryo death
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• spongiotrophoblast fails to develop
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Allelic Composition |
Ascl2tm1Alj/Ascl2+
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|
Genetic Background |
involves: 129 * CD-1 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl2tm1Alj mutation
(0 available);
any
Ascl2 mutation
(15 available)
|
|
|
mortality/aging
|
• maternal inheritance of the mutant allele leads to embryonic death due to placental failure
• mice whom paternally inherit the mutant allele are viable
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embryo
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• chorion membrane is underdeveloped in embryos whom maternally inherit the mutant allele
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• spongiotrophoblast fails to develop in embryos whom maternally inherit the mutant allele
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cellular
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• the paternal allele is functionally inactivated
• mice whom maternally inherit the mutant allele are functionally null homozygotes and die during embryogenesis
• mice whom paternally inherit the mutant allele are viable
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl2tm1Alj mutation
(0 available);
any
Ascl2 mutation
(15 available)
Kcnq1ot1tm1.1Mjh mutation
(0 available);
any
Kcnq1ot1 mutation
(0 available)
|
|
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embryo
N |
• no embryonic lethality is observed in mice maternally inheriting the Ascl2tm1Alj allele
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cellular
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• embryonic lethality associated with maternal transmission of Ascl2tm1Alj allele is prevented by the addition of the Kcnq1tm1.1Mjh allele due to a lack of paternal imprinting of genes in the distal portion of chromosome 7
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