Phenotypes associated with this allele

• Allele Symbol: Ntf3⁺
• Allele Name: wild type
• Allele ID: MGI:2153755
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ntf3^tm1Par/Ntf3^+	involves: 129S1/Sv	MGI:3620535
ht2	Ntf3^tm1Mpin/Ntf3^+	involves: 129S1/Sv	MGI:3819973
ht3	Ntf3^tm1Jae/Ntf3^+	involves: 129S4/SvJae * BALB/c	MGI:2175177
cn4	Ntf3^tm2Jae/Ntf3^+ Tg(Tagln-cre)1Her/0	involves: 129S1/Sv * C57BL/6 * SJL	MGI:5559202
cx5	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf3^tm1Jae/Ntf3^+	involves: 129S4/SvJae * BALB/c	MGI:3770676

Genotype
MGI:3620535

ht1

• Allelic Composition: Ntf3^tm1Par/Ntf3⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:35639 )

• although a range of heart defects are observed, individual heterozygotes usually only display one of the abnormalities

anomalous pulmonary venous connection ( J:35639 )

• anomalous pulmonary venous return

ostium secundum atrial septal defect ( J:35639 )

• small atrial septal secundum defects

thick pulmonary valve cusps ( J:35639 )

• thickening of pulmonic valve lefalets

heart right ventricle outflow tract stenosis ( J:35639 )

• subpulmonic stenosis

pulmonary valve stenosis ( J:35639 )

increased heart right ventricle size ( J:35639 )

• 3 of 5 show moderate right ventricular enlargement

Genotype
MGI:3819973

ht2

• Allelic Composition: Ntf3^tm1Mpin/Ntf3⁺
• Genetic Background: involves: 129S1/Sv

nervous system

nervous system phenotype ( J:79302 )

N • despite the loss of cutaneous axons and hair receptors, mice exhibit no evidence of demyelination or axonal degeneration and the coding properties of remaining receptors and axons are normal

abnormal sensory neuron innervation pattern ( J:79302 )

• mice exhibit loss of cutaneous myelinated axons to 76% of wild-type

• most of the axons lost are in the larger size range with some smaller sized axons also lost

• mice exhibit a 78% reduction in the incidence of SA-type afferents with a corresponding increase in RA-type afferents (from 52% to 90%) among Abeta afferents compared to in wild-type mice

• mice exhibit a loss of Adelta axons of 3 to 3.5 um in diameter compared to in wild-type mice

abnormal cutaneous/subcutaneous mechanoreceptor morphology ( J:79302 )

• D-hair receptors are reduced 50% compared to in wild-type mice

abnormal Merkel's receptor morphology ( J:79302 )

• mice exhibit a reduction to 15% of wild-type in the average number of Merkel cells per complex

• at P14, the total number of Merkel cells is decreased to 50% of wild-type

• however, at P2 the number of Merkel cells and their innervation is normal

Genotype
MGI:2175177

ht3

• Allelic Composition: Ntf3^tm1Jae/Ntf3⁺
• Genetic Background: involves: 129S4/SvJae * BALB/c

nervous system

abnormal stellate ganglion morphology ( J:62748 )

• fewer stellate ganglion neurons at P0 and P60 than in wild-type

decreased sensory neuron number ( J:53825 )

• mice exhibit a 17% loss in sensory neurons in the dorsal root ganglion

abnormal dorsal root ganglion morphology ( J:53825 )

• mice exhibit a loss of myelinated fibers in the dorsal root ganglion

cardiovascular system

abnormal cardiovascular system physiology ( J:62748 )

• adults exhibit lower sympathetic tonus than wild-type

decreased heart rate ( J:62748 )

• adults exhibit lower resting heart rates than wild-type

homeostasis/metabolism

abnormal noradrenaline level ( J:62748 )

• 37% decrease in adult heart ventricular norepinephrine concentrations, however no differences seen at birth

muscle

abnormal muscle morphology ( J:53825 , J:23882 )

• muscles exhibit fewer myelinated fibers than in wild-type mice (52+/-4 compared to 76+/-2 in wild-type mice) (J:53825)

• 50% reduction of muscle spindles (J:23882)

Genotype
MGI:5559202

cn4

• Allelic Composition: Ntf3^tm2Jae/Ntf3⁺; Tg(Tagln-cre)1Her/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

behavior/neurological

abnormal eating behavior ( J:201812 )

• mice exhibit increased meal duration with reduced rate of food intake compared with control mice

• however, meal size is normal

Genotype
MGI:3770676

cx5

• Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae; Ntf3^tm1Jae/Ntf3⁺
• Genetic Background: involves: 129S4/SvJae * BALB/c

mortality/aging

postnatal lethality, incomplete penetrance ( J:53825 )

• few mice survive past 3 weeks of age

nervous system

decreased muscle spindle number ( J:53825 )

• spindle density in the soleus, the medial gastrocnemius, plantaris and lumbrical muscles is reduced 50% compared to in wild-type mice

absent muscle spindles ( J:53825 )

• 31% of soleus muscles are devoid of muscle spindles

decreased sensory neuron number ( J:53825 )

• mice exhibit a 78% loss in sensory neurons in the dorsal root ganglion

abnormal dorsal root ganglion morphology ( J:53825 )

• mice exhibit a loss of 82% myelinated fibers in the dorsal root ganglion

• mice exhibit a loss of 75% of dorsal root ganglion neurons

abnormal proprioceptive neuron morphology ( J:53825 )

• at E14.5, Ia neuron projections in the dorsal root ganglion are severely reduced

• mice exhibit a 90% loss of proprioreceptive neurons in the dorsal root ganglion

small L4 dorsal root ganglion ( J:53825 )

• at E14.5, L4 is smaller than in wild-type mice due to a 12.1-fold increase in apoptosis

behavior/neurological

dystonia ( J:53825 )

• mice exhibit dystonia during the first two weeks after birth but not during adulthood

ataxia ( J:53825 )

• mice exhibit ataxia during the first two weeks after birth but not during adulthood

abnormal gait ( J:53825 )

• mice exhibit an unstable gait and mild posturing of extremities during the first two weeks after birth but not during adulthood

muscle

dystonia ( J:53825 )

• mice exhibit dystonia during the first two weeks after birth but not during adulthood

abnormal muscle morphology ( J:53825 )

• muscles exhibit fewer myelinated fibers than in wild-type mice (26+/-2 compared to 76+/-2 in wild-type mice)

decreased muscle spindle number ( J:53825 )

• spindle density in the soleus, the medial gastrocnemius, plantaris and lumbrical muscles is reduced 50% compared to in wild-type mice

absent muscle spindles ( J:53825 )

• 31% of soleus muscles are devoid of muscle spindles

muscle spasm ( J:53825 )

• mice that survive longer than 3 weeks exhibit flexor spasms and uplifting of hindlimbs during weeks 3 to 4

growth/size/body

decreased body weight ( J:53825 )

• mice weight 10% to 30% less than wild-type mice