Phenotypes associated with this allele
Allelic Composition |
Matn1tm1Ref/Matn1tm1Ref
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Genetic Background |
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Matn1tm1Ref mutation
(0 available);
any
Matn1 mutation
(20 available)
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skeleton
N |
• no skeletal malformations at E17.5, during the neonatal period or at 4-8 weeks after birth
(J:67300)
• normal limb and trunk development up to 1 year of age
(J:67300)
• normal chondrocyte morphology and endochondral bone formation
(J:67300)
• normal collagen fibrillar network in the extracellular matrix
(J:67300)
• no compensatory up-regulation of other matrilins in mutant cartilage
(J:67300)
• normal expression levels and extractability profiles of both collagen II and aggrecan in mutant epiphyseal cartilage
(J:67300)
(J:117910)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Matn1tm1Ref mutation
(0 available);
any
Matn1 mutation
(20 available)
Matn2tm1Asz mutation
(0 available);
any
Matn2 mutation
(54 available)
Matn3tm1Asz mutation
(0 available);
any
Matn3 mutation
(26 available)
Matn4tm1.1Asz mutation
(0 available);
any
Matn4 mutation
(17 available)
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cellular
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• mice show increased proliferation and expansion of HSCs after myelosuppressive chemotherapy (treatment with 5-FU), inflammatory stress (treatment with pI:C) and transplantation (increased competitive repopulation capacity)
• untreated LSK cells exhibit a higher colony-forming potential than wild-type cells, with larger and more colonies, which is more pronounced in secondary colony forming units
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hematopoietic system
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• mice show increased proliferation and expansion of HSCs after myelosuppressive chemotherapy (treatment with 5-FU), inflammatory stress (treatment with pI:C) and transplantation (increased competitive repopulation capacity)
• untreated LSK cells exhibit a higher colony-forming potential than wild-type cells, with larger and more colonies, which is more pronounced in secondary colony forming units
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• slight decrease in T cells (CD4+CD8+)
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• slight increase in megakaryocytes (CD41+)
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• slight decrease in erythrocytes (Terr119+)
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• slight increase in granulocytes (CD11b+Gr-1+)
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• mice exhibit decreased Lin-Sca-1+cKit+ (LSK) numbers
• however, quiescent hematopoietic stem cell (HSC) and long term-hematopoietic stem cell (LT-HSC) numbers are normal and amounts of myeloid and lymphoid lineages are normal, with only minor differences in T cells and granulocytes
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homeostasis/metabolism
immune system
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• slight decrease in T cells (CD4+CD8+)
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• slight increase in granulocytes (CD11b+Gr-1+)
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