Phenotypes associated with this allele

• Allele Symbol: Itgb4^tm1Son
• Allele Name: targeted mutation 1, Arnoud Sonnenberg
• Allele ID: MGI:2152982
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb4^tm1Son/Itgb4^tm1Son	129P2/OlaHsd-Itgb4^tm1Son	MGI:3836387

Genotype
MGI:3836387

hm1

• Allelic Composition: Itgb4^tm1Son/Itgb4^tm1Son
• Genetic Background: 129P2/OlaHsd-Itgb4^tm1Son

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:33713 )

• mice die within 2 hours of birth

digestive/alimentary system

abnormal tongue epithelium morphology ( J:33713 )

• mice exhibit detachment of the tongue epithelium unlike in wild-type mice

vision/eye

abnormal cornea morphology ( J:33713 )

• corneal edema

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:33713 )

• mice exhibit detachment of the bladder epithelium unlike in wild-type mice

respiratory system

abnormal olfactory epithelium morphology ( J:33713 )

• mice develop calcifications of the nasal epithelium unlike in wild-type mice

immune system

immune system phenotype ( J:33713 )

N • T cell development is normal

nervous system

nervous system phenotype ( J:33713 )

N • myelination is normal

homeostasis/metabolism

edema ( J:33713 )

• corneal edema

taste/olfaction

abnormal olfactory epithelium morphology ( J:33713 )

• mice develop calcifications of the nasal epithelium unlike in wild-type mice

craniofacial

abnormal tongue epithelium morphology ( J:33713 )

• mice exhibit detachment of the tongue epithelium unlike in wild-type mice

abnormal olfactory epithelium morphology ( J:33713 )

• mice develop calcifications of the nasal epithelium unlike in wild-type mice

integument

abnormal nail morphology ( J:33713 )

• the epidermis separates from the dermis including the nail bed together with the nail unlike in wild-type mice

abnormal keratinocyte morphology ( J:33713 )

• basal keratinocytes lack hemidesmosomes

• however, desmosomes are present in some cells

dermal-epidermal separation ( J:33713 )

• the epidermis separates from the dermis including the nail bed together with the nail unlike in wild-type mice

• mice exhibit dermo-epidermal splits through the lamina lucida

abnormal skin condition ( J:33713 )

• within 15 to 30 minutes of birth mice exhibit detachment of their epidermis over large parts of their bodies unlike in wild-type mice

growth/size/body

abnormal tongue epithelium morphology ( J:33713 )

• mice exhibit detachment of the tongue epithelium unlike in wild-type mice

abnormal olfactory epithelium morphology ( J:33713 )

• mice develop calcifications of the nasal epithelium unlike in wild-type mice