Analysis Tools
nervous system
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• despite disruption in some sensory neuron afferents, development of inner ear spiral neurons and the development of inner and outer hair cell innervation are normal
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• mice lack muscle spindles in axial paraspinal muscles, hind limbs or fore limbs unlike in wild-type mice likely due to an absence of Ia afferent projections
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• mice exhibit a 50% reduction in the number of fibers projecting from the tibial nerve to the soleus muscle compared to in wild-type mice
• unlike in Ntf3 knock-out mice, central neuronal fibers project ventrally in the spinal cord at E15.5
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• the neurons in the spiral ganglion are almost completely rescued (up to 85% of wild-type)
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• fewer neurons are found in the dorsal root ganglia of C1, T1 and L1 than in wild-type but there are more neurons in these areas than in Ntf3 knock-out mice
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• however, Ntrk2+ neurons are present in the dorsal root ganglion and project fibers into the spinal cord
• at E12.5 and E13.5, Ntrk3+ neurons are missing from the dorsal root ganglion
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• innervation of the three rows of outer hair cells is somewhat disorganized and increased in density compared to in wild-type mice
• however, radial fibers are completely restored to the basal turn of the cochlea
• increased innervation density of the cochlea is associated with the presence of aberrant fiber bundles that pass underneath the organ of Corit spiraling in a longitudinal bundle underneath the outer hair cells, that spiral between radial fibers near the inner hair cells and that never enter the organ of Corti but run beneath the tympanic border cells near the inner hair cells and the outer hair cells unlike in wild-type mice
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• at P0, mice lack proprioceptive neurons and projecting fibers that form during embryogenesis fail to differentiate and degenerate at birth
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• at E12.5 and E13.5, Ntrk3+ neurons are missing from the dorsal root ganglion
• however, Ntrk2+ neurons are present in the dorsal root ganglion and project fibers into the spinal cord
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behavior/neurological
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• mice exhibit abnormal movement indicative of loss of proprioception
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muscle
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• mice lack muscle spindles in axial paraspinal muscles, hind limbs or fore limbs unlike in wild-type mice likely due to an absence of Ia afferent projections
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