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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdk4+
wild type
MGI:2152765
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Cdk4tm1b(NCOM)Mfgc/Cdk4+ C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp MGI:5797427
ht2
 		Cdk4tm1.1Bbd/Cdk4+ involves: 129S1/Sv * 129X1/SvJ * ICR MGI:2386972
cn3
 		Cdk4tm1.1Bbd/Cdk4+
Krastm1Bbd/Kras+
Tg(CMV-cre)1Cgn/? 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 MGI:3582836
cx4
 		Cdk4tm1.1Bbd/Cdk4+
Tg(Mt1-Hgf)#Lmb/0 		B6.Cg-Cdk4tm1.1Bbd Tg(Mt1-Hgf)#Lmb MGI:6259577
cx5
 		Cdk4+/Cdk4+
Tg(Mt1-Hgf)#Lmb/0 		B6.Cg-Cdk4tm1.1Bbd Tg(Mt1-Hgf)#Lmb MGI:6259550
cx6
 		Cdk4tm1Kiyo/Cdk4+
Lin9tm1Orc/Lin9+ 		involves: 129S1/Sv MGI:3712956
cx7
 		Cdk2tm1Sgo/Cdk2+
Cdk4tm2.1Bbd/Cdk4+ 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL MGI:3759576


Genotype
MGI:5797427
ht1
Allelic
Composition		 Cdk4tm1b(NCOM)Mfgc/Cdk4+
Genetic
Background		 C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp
Cell Lines M00049_C_390W_F08
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1b(NCOM)Mfgc mutation (1 available); any Cdk4 mutation (57 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

growth/size/body
decreased body length ( J:211773 )
IMPC - TCP

hematopoietic system

skeleton




Genotype
MGI:2386972
ht2
Allelic
Composition		 Cdk4tm1.1Bbd/Cdk4+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1.1Bbd mutation (0 available); any Cdk4 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pancreatic beta cell number ( J:54534 )
• pancreatic islet hyperplasia due to increased beta-cell number, but to a lesser extent than in homozygous mice




Genotype
MGI:3582836
cn3
Allelic
Composition		 Cdk4tm1.1Bbd/Cdk4+
Krastm1Bbd/Kras+
Tg(CMV-cre)1Cgn/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1.1Bbd mutation (0 available); any Cdk4 mutation (57 available)
Krastm1Bbd mutation (2 available); any Kras mutation (88 available)
Tg(CMV-cre)1Cgn mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenoma incidence ( J:86101 )
• latency to develop lung adenomas is significantly shorter compared to double mutants wild-type for Cdk4; however development of tumors characteristic of Cdk4tm1.1Bbd mutant mice is not accelerated
increased sarcoma incidence ( J:86101 )
• histiocytic sarcoma and other sarcomas are seen
increased papilloma incidence ( J:86101 )
• anal papillomas are seen

digestive/alimentary system
abnormal pancreatic duct morphology ( J:86101 )
• focal metaplasia in the pancreatic ducts consisting of tall columnar cells with abundant apical mucin resembling gastric surface epithelial cells

endocrine/exocrine glands
abnormal pancreatic duct morphology ( J:86101 )
• focal metaplasia in the pancreatic ducts consisting of tall columnar cells with abundant apical mucin resembling gastric surface epithelial cells

nervous system

respiratory system
increased lung adenoma incidence ( J:86101 )
• latency to develop lung adenomas is significantly shorter compared to double mutants wild-type for Cdk4; however development of tumors characteristic of Cdk4tm1.1Bbd mutant mice is not accelerated




Genotype
MGI:6259577
cx4
Allelic
Composition		 Cdk4tm1.1Bbd/Cdk4+
Tg(Mt1-Hgf)#Lmb/0
Genetic
Background		 B6.Cg-Cdk4tm1.1Bbd Tg(Mt1-Hgf)#Lmb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1.1Bbd mutation (0 available); any Cdk4 mutation (57 available)
Tg(Mt1-Hgf)#Lmb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:111992 )
• in a 2-step (DMBA/TPA) skin carcinogenesis protocol, all (15 of 15) mice develop progressively growing melanomas and have to be sacrificed between 14 and 16 weeks of age with an average of 32 cutaneous melanomas
• DMBA/TPA-induced melanomas involve the epidermo-dermal junction and show vertical invasive growth in the underlying dermis
• only 3 of 15 DMBA/TPA-treated mice develop a single papilloma in skin
increased metastatic potential ( J:111992 )
• DMBA/TPA-treated mice show locoregional metastatic growth of melanoma cells in draining lymph nodes as well as numerous melanoma micrometastases in lung tissue
• in lymph nodes of DMBA/TPA-treated mice, melanoma cells are mostly spindle-shaped cells with little/no melanin that eventually disrupt lymph node architecture and displace lymphoid cells; however, heavily pigmented epitheloid melanoma cells are also observed
• in DMBA/TPA-treated mice, the average number of lung metastases is comparable to that in Tg(Mt1-HGFSF)#Lmb/0 mice
decreased tumor growth/size ( J:111992 )
• DMBA/TPA-induced melanomas grow with a slight delay relative to those in Cdk4tm1.1Bbd/Cdk4tm1.1Bbd Tg(Mt1-HGFSF)#Lmb/0 mice

immune system
abnormal axillary lymph node morphology ( J:111992 )
• at sacrifice, DMBA/TPA-treated mice show heavily pigmented axillary lymph nodes
enlarged axillary lymph nodes ( J:111992 )
• at sacrifice, DMBA/TPA-treated mice show enlarged axillary lymph nodes due to growth of melanoma cells
abnormal inguinal lymph node morphology ( J:111992 )
• at sacrifice, DMBA/TPA-treated mice show heavily pigmented inguinal lymph nodes
enlarged inguinal lymph nodes ( J:111992 )
• at sacrifice, DMBA/TPA-treated mice show enlarged inguinal lymph nodes due to growth of melanoma cells

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:111992 )
• in a 2-step (DMBA/TPA) skin carcinogenesis protocol, all (15 of 15) mice develop progressively growing melanomas and have to be sacrificed between 14 and 16 weeks of age with an average of 32 cutaneous melanomas
• DMBA/TPA-induced melanomas involve the epidermo-dermal junction and show vertical invasive growth in the underlying dermis
• only 3 of 15 DMBA/TPA-treated mice develop a single papilloma in skin




Genotype
MGI:6259550
cx5
Allelic
Composition		 Cdk4+/Cdk4+
Tg(Mt1-Hgf)#Lmb/0
Genetic
Background		 B6.Cg-Cdk4tm1.1Bbd Tg(Mt1-Hgf)#Lmb
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:111992 )
• in a 2-step (DMBA/TPA) skin carcinogenesis protocol, all (18 of 18) mice develop slowly growing skin melanomas with an average of 12 cutaneous melanomas
• DMBA/TPA-induced melanomas involve the epidermo-dermal junction and show vertical invasive growth into the dermis; however, no proliferative activity of melanoma cells is detected by Ki67 staining
• 10 of 18 DMBA/TPA-treated mice also develop large subcutaneous cystic tumors filled with serous liquid and have to be sacrificed by 30 weeks of age
• all DMBA/TPA-treated mice develop on average 3 papillomas in the skin; these appear early after carcinogen treatment
increased skin nevi incidence ( J:111992 )
• at 30 weeks of age, untreated mice exhibit melanocytic nevi in skin
• however, untreated mice are all alive and healthy at 1 year of age
increased metastatic potential ( J:111992 )
• DMBA/TPA-treated mice show locoregional metastatic growth of melanoma cells in draining lymph nodes as well as numerous melanoma micrometastases in lung tissue
• in lymph nodes of DMBA/TPA-treated mice, melanoma cells are mainly spindle-shaped cells with little/no melanin that eventually disrupt lymph node architecture and displace lymphoid cells; however, heavily pigmented epitheloid melanoma cells are also observed
• in DMBA/TPA-treated mice, the average number of lung metastases is comparable to that in Cdk4tm1.1Bbd/Cdk4+ Tg(Mt1-HGFSF)#Lmb/0 mice

integument
increased skin nevi incidence ( J:111992 )
• at 30 weeks of age, untreated mice exhibit melanocytic nevi in skin
• however, untreated mice are all alive and healthy at 1 year of age

immune system
abnormal axillary lymph node morphology ( J:111992 )
• at sacrifice, DMBA/TPA-treated mice show heavily pigmented axillar lymph nodes
abnormal inguinal lymph node morphology ( J:111992 )
• at sacrifice, DMBA/TPA-treated mice show heavily pigmented inguinal lymph nodes

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:111992 )
• in a 2-step (DMBA/TPA) skin carcinogenesis protocol, all (18 of 18) mice develop slowly growing skin melanomas with an average of 12 cutaneous melanomas
• DMBA/TPA-induced melanomas involve the epidermo-dermal junction and show vertical invasive growth into the dermis; however, no proliferative activity of melanoma cells is detected by Ki67 staining
• 10 of 18 DMBA/TPA-treated mice also develop large subcutaneous cystic tumors filled with serous liquid and have to be sacrificed by 30 weeks of age
• all DMBA/TPA-treated mice develop on average 3 papillomas in the skin; these appear early after carcinogen treatment




Genotype
MGI:3712956
cx6
Allelic
Composition		 Cdk4tm1Kiyo/Cdk4+
Lin9tm1Orc/Lin9+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1Kiyo mutation (0 available); any Cdk4 mutation (57 available)
Lin9tm1Orc mutation (0 available); any Lin9 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:111333 )
• number of MEF cells in S-phase is increased by 2.3-fold

immune system
decreased susceptibility to autoimmune diabetes ( J:111333 )
• mice do not develop early onset diabetes




Genotype
MGI:3759576
cx7
Allelic
Composition		 Cdk2tm1Sgo/Cdk2+
Cdk4tm2.1Bbd/Cdk4+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2tm1Sgo mutation (1 available); any Cdk2 mutation (16 available)
Cdk4tm2.1Bbd mutation (1 available); any Cdk4 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:125217 )
• 60% of mice do not complete embryonic development




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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory