All Phenotypes App<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

App⁺
wild type
MGI:2152748

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	App^{tm1b(KOMP)Wtsi}/App⁺	C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics	MGI:5756718
ht2	App^tm1Cep/App⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:2652361
ht3	App^tm1.1Cep/App⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:2652363
ht4	App^tm1Ini/App⁺	involves: C57BL/6 * CBA * CD-1	MGI:3044184
cx5	App^tm1Dbo/App⁺ Dab1^tm1Bwh/Dab1^tm1Bwh	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6	MGI:3810281
cx6	App^tm1Dbo/App⁺ Lrp4^tm1Her/Lrp4^tm1Her	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J	MGI:5561077

Allelic Composition	App^{tm1b(KOMP)Wtsi}/App⁺
Genetic Background	C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
Cell Lines	EPD0797_6_F12

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^{tm1b(KOMP)Wtsi} mutation (0 available); any App mutation (111 available)

Data Sources

IMPC Data for App

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - ICS

hematopoietic system

increased neutrophil cell number ( J:211773 )

IMPC - ICS

increased monocyte cell number ( J:211773 )

IMPC - ICS

homeostasis/metabolism

increased blood urea nitrogen level ( J:211773 )

IMPC - ICS

increased circulating calcium level ( J:211773 )

IMPC - ICS

immune system

increased neutrophil cell number ( J:211773 )

IMPC - ICS

increased monocyte cell number ( J:211773 )

IMPC - ICS

limbs/digits/tail

short tibia ( J:211773 )

IMPC - ICS

skeleton

short tibia ( J:211773 )

IMPC - ICS

vision/eye

increased cornea thickness ( J:211773 )

IMPC - ICS

decreased total retina thickness ( J:211773 )

IMPC - ICS

Allelic Composition	App^tm1Cep/App⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1Cep mutation (0 available); any App mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:35500 )

• increased amyloidogenic processing of App

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:35500

Allelic Composition	App^tm1.1Cep/App⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1.1Cep mutation (0 available); any App mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:35500 )

• increased amyloidogenic processing of App

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:35500

Allelic Composition	App^tm1Ini/App⁺
Genetic Background	involves: C57BL/6 * CBA * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1Ini mutation (0 available); any App mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:90296 )

• moderately accelerated mortality among females only after 56 weeks of age

• by 125 weeks of age survival was about 48.5% as opposed to 62.2% in controls

behavior/neurological

abnormal learning/memory/conditioning ( J:90296 )

abnormal long-term object recognition memory ( J:90296 )

• slower at a water finding test at 27 months of age, no difference when tested at 6 months of age

abnormal spatial learning ( J:90296 )

• females were slower at spatial memory acquisition

abnormal locomotor behavior ( J:90296 )

• males were quicker to begin exploration in open field tests

increased locomotor activity ( J:90296 )

• overall locomotor activity was increased in males

nervous system

amyloid beta deposits ( J:90296 )

• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form

abnormal telencephalon morphology ( J:90296 )

• no signs of neuritic plaque or neurofibrillar tangle formation

homeostasis/metabolism

amyloid beta deposits ( J:90296 )

• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:90296

Allelic Composition	App^tm1Dbo/App⁺ Dab1^tm1Bwh/Dab1^tm1Bwh
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1Dbo mutation (4 available); any App mutation (111 available)
Dab1^tm1Bwh mutation (0 available); any Dab1 mutation (77 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

small cerebellum ( J:132599 )

• the cerebellum volume is not as small as in Dab1^tm1Bwh homozygotes

Allelic Composition	App^tm1Dbo/App⁺ Lrp4^tm1Her/Lrp4^tm1Her
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1Dbo mutation (4 available); any App mutation (111 available)
Lrp4^tm1Her mutation (1 available); any Lrp4 mutation (96 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:207796 )

• 20 of 49 mice die within 5 months

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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