Phenotypes associated with this allele

• Allele Symbol: Apoe⁺
• Allele Name: wild type
• Allele ID: MGI:2152735
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Apoe^tm1Bres/Apoe^+	either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)	MGI:2174913
ht2	Apoe^tm1Unc/Apoe^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3836194
ht3	Apoe^tm1Lmh/Apoe^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:2174930
cx4	Apoe^tm1Unc/Apoe^+ Cyp4f13^Gt(OST14770)Lex/Cyp4f13^Gt(OST14770)Lex	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6	MGI:6455725
cx5	Apoe^tm1Unc/Apoe^+ Tg(APPV717I)1130Kha/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3722317

Genotype
MGI:2174913

ht1

• Allelic Composition: Apoe^tm1Bres/Apoe⁺
• Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal digestive system physiology ( J:2809 )

• a vitamin A-fat tolerance test suggests a mild defect in dietary fat clearance

homeostasis/metabolism

increased circulating cholesterol level ( J:2809 )

• total cholesterol is slightly but significantly elevated to 81 +/- 18 mg/dl compared to 60 +/- 20 mg/dl in wild-type mice

• on a high fat high cholesterol diet total cholesterol is not significantly different from wild-type mice

Genotype
MGI:3836194

ht2

• Allelic Composition: Apoe^tm1Unc/Apoe⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

homeostasis/metabolism

increased circulating triglyceride level ( J:16573 )

• circulating triglyceride levels are 39% higher than in wild-type controls

Genotype
MGI:2174930

ht3

• Allelic Composition: Apoe^tm1Lmh/Apoe⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

cardiovascular system

atherosclerotic lesions ( J:22347 )

• atherosclerosis, when fed hypercholesterolemic diet for 14 weeks after weaning

• surface area of lesions was 6 - 30 times larger than sex-matched controls

• lesions in females larger than in males

homeostasis/metabolism

abnormal lipid homeostasis ( J:22347 )

increased circulating cholesterol level ( J:22347 )

• mild hypercholesterolemia when fed a hypercholesterolemic diet with 20-fold increase in serum cholesterol resulting

• no increase in HDL

increased circulating HDL cholesterol level ( J:22347 )

• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

increased circulating VLDL cholesterol level ( J:22347 )

• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

Genotype
MGI:6455725

cx4

• Allelic Composition: Apoe^tm1Unc/Apoe⁺; Cyp4f13^{Gt(OST14770)Lex}/Cyp4f13^{Gt(OST14770)Lex}
• Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

cardiovascular system

decreased susceptibility to atherosclerosis ( J:289999 )

• smaller lesions in female and male mice fed a high-fat diet

Genotype
MGI:3722317

cx5

• Allelic Composition: Apoe^tm1Unc/Apoe⁺; Tg(APPV717I)1130Kha/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

mortality/aging

premature death ( J:43446 )

• absence of Apoe does not modify or improve mouse survival relative to Tg(APPV717I)1130Kha mice expressing Apoe; significant mortality before 150 days of age is observed