Analysis Tools
mortality/aging
|
• 59.9% of mice die by 20 weeks of age due to complications from thymoma
• mortality rates are higher in females (73.9% mortality at 20 weeks of age) than males (41.7% mortality)
• only 5 of 82 mice lived longer than 60 weeks
|
neoplasm
|
• thymomas develop with a high penentrance in this transgenic line but not other lines
• thymomas do not express the transgene
• tumor progression is more aggressive in females (73.9% mortality at 20 weeks of age) than males (41.7% mortality)
• thymomas are of epithelial origin with desmosomes, cilia, and tonofibrils all evident within the tumor cells
|
cardiovascular system
|
• the vena cava is often ruptured by thymomas leading to death of the mouse
|
respiratory system
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• mice display respiratory distress as they age
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liver/biliary system
|
• all mice exhibit liver congestion
|
vision/eye
exophthalmos
(
J:59903
)
|
• all mice exhibit this
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homeostasis/metabolism
|
• mice develop edema as they age
|
endocrine/exocrine glands
|
• thymomas develop with a high penentrance in this transgenic line but not other lines
• thymomas do not express the transgene
• tumor progression is more aggressive in females (73.9% mortality at 20 weeks of age) than males (41.7% mortality)
• thymomas are of epithelial origin with desmosomes, cilia, and tonofibrils all evident within the tumor cells
|
