Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahrtm1Gonz mutation
(1 available);
any
Ahr mutation
(107 available)
|
|
|
homeostasis/metabolism
reproductive system
|
N |
• mammary gland development is normal
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahrtm1Gonz mutation
(1 available);
any
Ahr mutation
(107 available)
|
|
|
mortality/aging
|
|
• unlike C57BL/6-Ahrb-1 neonates, mice are not susceptible to lethality induced by in utero exposure to cHBB
|
reproductive system
|
|
• mice produce smaller litters than wild-type mice
• however, exposure to cHBB does not further decrease fecundity
|
homeostasis/metabolism
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahrtm1Gonz mutation
(1 available);
any
Ahr mutation
(107 available)
|
|
|
mortality/aging
|
|
• over 20% are moribund by around 10 - 12 months of age
|
|
|
• about 40% - 50% of pups die within 1 - 4 days of birth
|
homeostasis/metabolism
reproductive system
 |
• in 12 retired breeders ecchymotic areas are seen on the serosa and are identified histologically by hypertrophy, thromboses, and mineralization of the serosal vessels
|
|
|
• after 3 - 4 cycles females have trouble maintaining pregnancies
|
|
|
• coincident with development of uterine lesions
|
immune system
|
|
• in about 80% of mice reduced T- and B-cell area is accompanied by mild to moderate splenomegaly
|
|
|
• myeloid hyperplasia of the red pulp is seen in mice with mild to moderate splenomegaly
|
|
|
• at 4 weeks of age; however, spleen architecture is similar to wild-type
|
|
|
• at 2 - 3 weeks of age, spleens contain 75 - 85% fewer lymphocytes; however the number of lymphocytes is similar to wild-type by 10 - 12 weeks of age
• at 25 - 32 weeks of age, lymphocyte numbers are about 50% of wild-type
• however, the proportion of B and T cells is similar to wild-type and thymus cellularity is similar to wild-type
|
|
|
• significant decrease in the size of the T- and B-cell zones and in the number of T- and B-cells in the spleen
|
|
|
• in pups that die postnatally lymphocyte infiltration is seen in many organs, particularly in the gut, urinary tract, and lung
|
|
|
• at 10 month of age, 25% of hearts display chronic, focal inflammation in the myocardium of the ventricles or atrium
|
|
|
• in some cases of rectal prolapse colonic hyperplasia and severe inflammation are also seen
• in mice with prolapse many helical bacteria are present in the crypts and significant titers of antibodies against Helicobacter hepaticus are detected
|
|
|
• mild to moderate inflammation is seen in some homozygotes
|
|
|
• ruptured follicles are associated with a mixed inflammatory cell infiltrate
|
liver/biliary system
|
|
• mild to moderate inflammation is seen in some homozygotes
|
|
|
• centrilobular hypercellularity
(J:25048)
• hepatic portal vascular lesions characterized by increased numbers of arteries and arterioles
(J:44690)
• however, Heliobacter hepaticus hepatitis is not seen
(J:44690)
|
|
|
• eosinophilia is seen in periportal hepatocytes
(J:25048)
• hepatocytomegalic periportal hepatocytes with eosinophilic cytoplasm
(J:44690)
|
|
|
• a 4 weeks of age, liver weight is 2.9 +/- 0.3% of body weight compared to 6.1 +/- 0.4% in wild-type mice
|
|
|
• pronounced fibrosis of the portal tract, visible at 3 weeks of age
(J:25048)
• minimal to mild portal fibrosis
(J:44690)
|
|
|
• seen in 1 of 12 mice at 11-13 months of age
|
|
|
• seen in 3 of 12 mice at 11-13 months of age
|
|
|
• constitutive expression of Cyp1a2 and Ugt1a6a are decreased by 90 +/- 5% and 85 +/- 5%, respectively, relative to wild-type mice
• liver glycogen depletion
|
growth/size/body
|
|
• seen around 9 months of age
|
|
|
• at 10 months of age, heart weight is increased to 0.8 +/- 0.13% of body weight compared to 0.47 +/- 0.06% in wild-type mice
|
|
|
• a 15 - 20% weight loss is seen in over 20% of mice by around 10 - 12 months of age
|
|
|
• slower growth rate within the first 2 - 4 weeks of life
|
|
|
• in about 80% of mice reduced T- and B-cell area is accompanied by mild to moderate splenomegaly
|
digestive/alimentary system
|
|
• in some cases of rectal prolapse colonic hyperplasia and severe inflammation are also seen
|
|
|
• at 6 - 13 months of age, 48% develop rectal prolapse
• in mice over 9 months of age, prolapse is characterized by marked epithelial hyperplasia and mucus secretion in the submucosa
• in mice with prolapse many helical bacteria are present in the crypts and significant titers of antibodies against Helicobacter hepaticus are detected; however prolapse has been seen in mice from 4 different animal facilities and mice with and without prolapse are seen in the same cage when housed in groups
|
|
|
• pyloric regions of the glandular stomach display focal, proliferative lesions with the highest incidence in mice over 9 months of age
• lesions start as focal hyperplasia and progress to large plaques or polyps
|
|
|
• lesions in the pyloric region of the glandular stomach start as focal hyperplasia and progress to large plaques or polyps
|
|
|
• seen in several homozygotes
|
|
|
• in some cases of rectal prolapse colonic hyperplasia and severe inflammation are also seen
• in mice with prolapse many helical bacteria are present in the crypts and significant titers of antibodies against Helicobacter hepaticus are detected
|
cardiovascular system
|
|
• mineralization of the serosal vessels in ecchymotic areas of the uterus
• hepatic portal vascular lesions characterized by increased numbers of arteries and arterioles
|
|
|
• at 10 month of age, almost 10% have enlarged coronary arteries and arterioles due to smooth muscle hypertrophy
|
|
|
• at 10 month of age, almost 10% have enlarged coronary arteries and arterioles due to smooth muscle hypertrophy
|
|
|
• seen around 9 months of age
|
|
|
• at 10 months of age, heart weight is increased to 0.8 +/- 0.13% of body weight compared to 0.47 +/- 0.06% in wild-type mice
|
|
|
• at 10 month of age, 25% of hearts display fibrosis in the myocardium of the ventricles or atrium
|
|
|
• at 10 month of age, 25% of hearts display chronic, focal inflammation in the myocardium of the ventricles or atrium
|
neoplasm
|
|
• seen in 1 of 12 mice at 11-13 months of age
|
|
|
• seen in 3 of 12 mice at 11-13 months of age
|
hematopoietic system
|
|
• in about 80% of mice reduced T- and B-cell area is accompanied by mild to moderate splenomegaly
|
|
|
• myeloid hyperplasia of the red pulp is seen in mice with mild to moderate splenomegaly
|
|
|
• at 4 weeks of age; however, spleen architecture is similar to wild-type
|
|
|
• at 2 - 3 weeks of age, spleens contain 75 - 85% fewer lymphocytes; however the number of lymphocytes is similar to wild-type by 10 - 12 weeks of age
• at 25 - 32 weeks of age, lymphocyte numbers are about 50% of wild-type
• however, the proportion of B and T cells is similar to wild-type and thymus cellularity is similar to wild-type
|
|
|
• significant decrease in the size of the T- and B-cell zones and in the number of T- and B-cells in the spleen
|
muscle
|
|
• at 10 month of age, almost 10% have enlarged coronary arteries and arterioles due to smooth muscle hypertrophy
|
integument
|
|
• make up 25 - 50% of plucked truncal pelage hairs rather than 10% as in wild-type mice
• hair fibers have worn rounded edges, worn cuticular scales, and some areas with small surface blebs with folding and breaking at the fold sites
|
|
|
• skin lesions usually begin with alopecia
|
|
|
• dystrophic follicles may have an abnormal hair fiber
|
|
|
• follicles are widely separated and dystrophic
• dystrophic follicles are empty, markedly dilated at the piliary canal and have either a structurally abnormal hair fiber or are ruptured
|
|
|
• ruptured follicles are associated with a mixed inflammatory cell infiltrate
|
|
|
• dilation of the piliary canal
|
|
|
• hypergranulosis is associated with the healing of skin ulcers
|
|
|
• mild to moderate acanthosis is associated with the healing of skin ulcers
|
|
|
• at 6 - 13 months of age, 53% develop dorsal, localized, thick, scaly skin
|
|
|
• progressive focal lesions are seen on the dorsal skin and in some mice extend to the ears and lateral aspects of the abdomen
• dermal mastocytosis is common in areas of inflamed skin
|
|
|
• skin lesions progress from alopecia to ulcers of variable severity
• ulcers heal by lateral hyperplasia of the intact epithelium with dermal scarring
|
|
|
• at 6 - 13 months of age, 53% develop dorsal, localized, thick, scaly skin
|
Analysis Tools