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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gna13tm1Soff
targeted mutation 1, Stefan Offermanns
MGI:2151775
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gna13tm1Soff/Gna13tm1Soff involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL MGI:3590663
hm2
 		Gna13tm1Soff/Gna13tm1Soff involves: 129S1/Sv * C57BL/6J MGI:2679956
cn3
 		Gna13tm1Soff/Gna13tm2Cgh
Tg(Tek-cre)1Ywa/0 		involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL MGI:3590664
cx4
 		Gna12tm1Citb/Gna12tm1Citb
Gna13tm1Soff/Gna13tm1Soff 		involves: 129S1/Sv * C57BL/6 MGI:3037546
cx5
 		Gna12tm1Citb/Gna12tm1Citb
Gna13tm1Soff/Gna13+ 		involves: 129S1/Sv * C57BL/6 MGI:3037547
cx6
 		Gna12tm1Citb/Gna12+
Gna13tm1Soff/Gna13+ 		involves: 129S1/Sv * C57BL/6 MGI:3037548
cx7
 		Gna12tm1Citb/Gna12+
Gna13tm1Soff/Gna13tm1Soff 		involves: 129S1/Sv * C57BL/6 MGI:3037549


Genotype
MGI:3590663
hm1
Allelic
Composition		 Gna13tm1Soff/Gna13tm1Soff
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:99731 )
• at E9.5 50% of mutants are dead and by E11.5 100% are dead

cardiovascular system
abnormal vitelline vasculature morphology ( J:99731 )
• large vessels are missing and unusually large vascular spaces are present
• this phenotype is more severe than in endothelial specific null mice
enlarged pericardium ( J:99731 )
• pericardial swelling
hemorrhage ( J:99731 )
• variable bleeding into cavities and tissues is seen and is more severe than in endothelial specific null mice

embryo
abnormal vitelline vasculature morphology ( J:99731 )
• large vessels are missing and unusually large vascular spaces are present
• this phenotype is more severe than in endothelial specific null mice
excessive folding of visceral yolk sac ( J:99731 )
• the yolk sac is wrinkled

growth/size/body
embryonic growth retardation ( J:99731 )

integument




Genotype
MGI:2679956
hm2
Allelic
Composition		 Gna13tm1Soff/Gna13tm1Soff
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:50566 )
• homozygous embryos are indistinguishable from wild-type at E8.5, but appear poorly developed and misshaped by E9.5 and undergo resorbtion by E10.5

cardiovascular system
abnormal blood vessel morphology ( J:50566 )
• blood vessels in mutant embryos were enlarged, with defects in the endothelial layer; ectopic vasculature and sporadic discontinuities were also noted, suggesting a failure to develop a functional vasculature system
abnormal angiogenesis ( J:50566 )
• endothelial cells were present throughout mutant embryos; defects occurred in the sprouting, growth, migration and remodeling of endothelial cells
absent vitelline blood vessels ( J:50566 )
• no vascular structures were present in yolk

embryo
absent vitelline blood vessels ( J:50566 )
• no vascular structures were present in yolk




Genotype
MGI:3590664
cn3
Allelic
Composition		 Gna13tm1Soff/Gna13tm2Cgh
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
Gna13tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:99731 )
• at E9.5 36% of mutants are dead and by E11.5 88% are dead

cardiovascular system
abnormal vitelline vasculature morphology ( J:99731 )
• large vessels are missing and unusually large vascular spaces are present; however this phenotype is more obvious in Gna13tm1Soff homozygous mice
enlarged pericardium ( J:99731 )
• pericardial swelling
hemorrhage ( J:99731 )
• variable bleeding into cavities and tissues is seen; however this phenotype is more obvious in Gna13tm1Soff homozygous mice

embryo
abnormal vitelline vasculature morphology ( J:99731 )
• large vessels are missing and unusually large vascular spaces are present; however this phenotype is more obvious in Gna13tm1Soff homozygous mice
excessive folding of visceral yolk sac ( J:99731 )
• the yolk sac is wrinkled

growth/size/body
embryonic growth retardation ( J:99731 )

integument




Genotype
MGI:3037546
cx4
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gna13tm1Soff/Gna13tm1Soff
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (21 available)
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:77728 )
• resorbed by E9.5 with severe necrosis

embryo
embryonic growth arrest ( J:77728 )
• arrest by E8.25




Genotype
MGI:3037547
cx5
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gna13tm1Soff/Gna13+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (21 available)
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3037548
cx6
Allelic
Composition		 Gna12tm1Citb/Gna12+
Gna13tm1Soff/Gna13+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (21 available)
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:77728 )
• mice are viable and fertile




Genotype
MGI:3037549
cx7
Allelic
Composition		 Gna12tm1Citb/Gna12+
Gna13tm1Soff/Gna13tm1Soff
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (21 available)
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth arrest ( J:77728 )
• growth arrest at E8.5




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory