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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxd4tm1Bhr
targeted mutation 1, Richard R Behringer
MGI:2151488
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxd4tm1Bhr/Hoxd4tm1Bhr involves: 129S/SvEv MGI:3611049
ht2
 		Hoxd4tm1Bhr/Hoxd4+ involves: 129S/SvEv MGI:3611050
cx3
 		Hoxd4tm1Bhr/Hoxd4tm1Bhr
Rargtm1Ipc/Rargtm1Ipc 		involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1 MGI:2668538
cx4
 		Hoxa4tm1Bhr/Hoxa4tm1Bhr
Hoxd4tm1Bhr/Hoxd4tm1Bhr 		involves: 129S/SvEv MGI:3611052
cx5
 		Hoxb4tm1Bay/Hoxb4tm1Bay
Hoxd4tm1Bhr/Hoxd4tm1Bhr 		involves: 129S/SvEv MGI:3611053
cx6
 		Hoxa4tm1Bhr/Hoxa4tm1Bhr
Hoxb4tm1Bay/Hoxb4tm1Bay
Hoxd4tm1Bhr/Hoxd4tm1Bhr 		involves: 129S/SvEv MGI:3611055


Genotype
MGI:3611049
hm1
Allelic
Composition		 Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd4tm1Bhr mutation (0 available); any Hoxd4 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal basioccipital bone morphology ( J:25267 )
• excessive basioccipital ossifications
increased rib number ( J:25267 )
• C7 ribs in 33% of homozygotes
abnormal cervical vertebrae morphology ( J:25267 )
• begin appearing around E14.5
• neural arch of C3 abnormal
• C7 ribs in 33% of homozygotes
abnormal cervical atlas morphology ( J:25267 )
• loss of components in C1
abnormal cervical axis morphology ( J:25267 )
• an anterior arch on C2
• lateral articular surfaces of C2 more like C1
• incomplete lateral foramina present in C2
abnormal odontoid process morphology ( J:25267 )
• greatly reduced dens
cervical vertebral transformation ( J:25267 )
• C2 to C1 transformation

craniofacial
abnormal basioccipital bone morphology ( J:25267 )
• excessive basioccipital ossifications




Genotype
MGI:3611050
ht2
Allelic
Composition		 Hoxd4tm1Bhr/Hoxd4+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd4tm1Bhr mutation (0 available); any Hoxd4 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased rib number ( J:25267 )
• C7 ribs in 17% of homozygotes
abnormal cervical vertebrae morphology ( J:25267 )
• C7 ribs in 17% of homozygotes
abnormal cervical axis morphology ( J:25267 )
• C2 to C1 transformation
cervical vertebral transformation ( J:25267 )
• C2 to C1 transformation




Genotype
MGI:2668538
cx3
Allelic
Composition		 Hoxd4tm1Bhr/Hoxd4tm1Bhr
Rargtm1Ipc/Rargtm1Ipc
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd4tm1Bhr mutation (0 available); any Hoxd4 mutation (12 available)
Rargtm1Ipc mutation (1 available); any Rarg mutation (151 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:58620 )
• considerably reduced

skeleton
abnormal basioccipital bone morphology ( J:58620 )
• malformed basioccipital bones in 1/3 of double homozygotes
abnormal cervical vertebrae morphology ( J:58620 )
• ectopic anterior arch on C3 in 83% of homozygotes
fusion of atlas and occipital bones ( J:58620 )
• basioccipital bone sometimes fuses to anterior arch of C1

reproductive system
male infertility ( J:58620 )
• homozygous males are infertile but homozygous females are fertile

craniofacial
abnormal basioccipital bone morphology ( J:58620 )
• malformed basioccipital bones in 1/3 of double homozygotes
fusion of atlas and occipital bones ( J:58620 )
• basioccipital bone sometimes fuses to anterior arch of C1




Genotype
MGI:3611052
cx4
Allelic
Composition		 Hoxa4tm1Bhr/Hoxa4tm1Bhr
Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa4tm1Bhr mutation (0 available); any Hoxa4 mutation (8 available)
Hoxd4tm1Bhr mutation (0 available); any Hoxd4 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal cervical vertebrae morphology ( J:27467 )
• dorsal cartilage between C2 and C3 fuses, penetrance 17%
• lateral ossified portions of C2 and C3 never fuse
• C7 ribs
cervical vertebral transformation ( J:27467 )
• large processus spinosi on both C2 and C3




Genotype
MGI:3611053
cx5
Allelic
Composition		 Hoxb4tm1Bay/Hoxb4tm1Bay
Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb4tm1Bay mutation (1 available); any Hoxb4 mutation (18 available)
Hoxd4tm1Bhr mutation (0 available); any Hoxd4 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:27467 )
• most homozygotes die within the first week of life but small numbers survive past six months

skeleton
abnormal cervical vertebrae morphology ( J:27467 )
• neural arches of C1 and C2 are often fused
cervical vertebral transformation ( J:27467 )
• almost complete C2 to C1 transformation
• C3 to C1 and C3 to C2 transformations
• C6 to C5 and C7 to C6 transformations
fusion of vertebral arches ( J:27467 )
• neural arches of C1 and C2 are often fused




Genotype
MGI:3611055
cx6
Allelic
Composition		 Hoxa4tm1Bhr/Hoxa4tm1Bhr
Hoxb4tm1Bay/Hoxb4tm1Bay
Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa4tm1Bhr mutation (0 available); any Hoxa4 mutation (8 available)
Hoxb4tm1Bay mutation (1 available); any Hoxb4 mutation (18 available)
Hoxd4tm1Bhr mutation (0 available); any Hoxd4 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal cervical vertebrae morphology ( J:27467 )
• atlas like anterior arches on C1 through C5
• lateral foramina on C2, C3, and C4
cervical vertebral transformation ( J:27467 )
• C6 to C5 and C7 to C6 transformations




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory